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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2005-1-5
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pubmed:abstractText |
Vasodilatation and increased capillary permeability have been proposed to be involved in the pathogenesis of acute and chronic form of hepatic encephalopathy. Prostacyclin (PGI2) and nitric oxide (NO) are important contributors to hyperdynamic circulation in portal hypertensive states. Our previous study showed that chronic inhibition of NO had detrimental effects on the severity of encephalopathy in thioacetamide (TAA)-treated rats due to aggravation of liver damage. To date, there are no detailed data concerning the effects of PGI2 inhibition on the severity of hepatic encephalopathy during fulminant hepatic failure.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1007-9327
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
14
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
232-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15633222-6-Ketoprostaglandin F1 alpha,
pubmed-meshheading:15633222-Animals,
pubmed-meshheading:15633222-Bilirubin,
pubmed-meshheading:15633222-Creatinine,
pubmed-meshheading:15633222-Disease Models, Animal,
pubmed-meshheading:15633222-Indomethacin,
pubmed-meshheading:15633222-Liver,
pubmed-meshheading:15633222-Liver Failure, Acute,
pubmed-meshheading:15633222-Motor Activity,
pubmed-meshheading:15633222-Prostaglandins I,
pubmed-meshheading:15633222-Rats,
pubmed-meshheading:15633222-Rats, Sprague-Dawley,
pubmed-meshheading:15633222-Thioacetamide,
pubmed-meshheading:15633222-Tumor Necrosis Factor-alpha
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pubmed:year |
2005
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pubmed:articleTitle |
Prostacyclin inhibition by indomethacin aggravates hepatic damage and encephalopathy in rats with thioacetamide-induced fulminant hepatic failure.
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pubmed:affiliation |
Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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