Linked Life Data

15630998

Source:http://linkedlifedata.com/resource/pubmed/id/15630998

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2005-1-5
pubmed:abstractText
Nitrogen oxide is a relatively stable, highly reactive radical, which develops in the organism by oxidation of the guanidine nitrogen of the amino acid L-arginine by the action of NO-synthase with the development of L-citrulline. It participates in a number of physiological and pathological processes. The difference between the physiological and pathological concentration of nitrogen oxide is very small, and for that reason we search for suitable methods of its determination and the substances influencing the level of nitrogen and thus decreasing its overproduction. Testing of scavenger activity against NO was performed by the method following Griess (spectrophotometric determination of nitrites as the oxidation products of NO), which was compared with the HPLC (high-performance liquid chromatography) method developed by the present authors. The antiradical effect of the compounds being assayed (acetylsalicylic acid, piracetam, paracetamol, serotonin, stobadin dihydrochloride, 5-hydroxy-L-tryptophan, N-acetyl-L-cysteine, L-glutathion, and N-acetyl-DL-penicillamine) against NO was compared with the so-called total antioxidant activity--TRAP (total radical-trapping antioxidant parameter), which corresponds to the capability to trap peroxyl radicals. On the basis of the obtained data, piracetam and acetylsalicylic acid show no antioxidant activity, paracetamol shows probably moderate scavenging action against nitrogen oxide, and other compounds tested (primarily 5-hydroxy-L-tryptophan, serotonin, stobadin) are strong antioxidants against both NO and peroxyl radical.
pubmed:language
cze
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1210-7816
pubmed:author
pubmed:issnType
Print
pubmed:volume
53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
310-3
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
[Determination of the antioxidant activity of potential scavengers of nitric oxide].
pubmed:affiliation
Ustav chemických léciv Farmaceutické fakulty VFU, Brno. kupkovaz@vfu.cz
pubmed:publicationType
Journal Article, English Abstract