Source:http://linkedlifedata.com/resource/pubmed/id/15629043
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2005-1-4
|
| pubmed:databankReference | |
| pubmed:abstractText |
In our previous studies, DAZAP2 gene expression was down-regulated in untreated patients of multiple myeloma (MM). For better studying the structure and function of DAZAP2, a full-length cDNA was isolated from mononuclear cells of a normal human bone marrow, sequenced and deposited to Genbank (AY430097). This sequence has an identical ORF (open reading frame) as the NM_014764 from human testis and the D31767 from human cell line KG-1. Phylogenetic analysis and structure prediction reveal that DAZAP2 homologues are highly conserved throughout evolution and share a polyproline region and several potential SH2/SH3 binding sites. DAZAP2 occurs as a single-copy gene with a four-exon organization. We further noticed that the functional DAZAP2 gene is located on Chromosome 12 and its pseudogene gene is on Chromosome 2 with electronic location of human chromosome in Genbank, though no genetic abnormalities of MM have been reported on Chromosome 12. The ORF of human DAZAP2 encodes a 17-kDa protein, which is highly similar to mouse Prtb. The DAZAP2 protein is mainly localized in cytoplasm with a discrete pattern of punctuated distribution. DAZAP2 may associate with carcinogenesis of MM and participate in yet-to-be identified signaling pathways to regulate proliferation and differentiation of plasma cells.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
1672-0229
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
2
|
| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
47-54
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:15629043-Amino Acid Sequence,
pubmed-meshheading:15629043-Base Sequence,
pubmed-meshheading:15629043-Chromosomes, Human, Pair 12,
pubmed-meshheading:15629043-Chromosomes, Human, Pair 2,
pubmed-meshheading:15629043-Cytoplasm,
pubmed-meshheading:15629043-DNA, Complementary,
pubmed-meshheading:15629043-DNA Primers,
pubmed-meshheading:15629043-Down-Regulation,
pubmed-meshheading:15629043-Gene Components,
pubmed-meshheading:15629043-Humans,
pubmed-meshheading:15629043-Likelihood Functions,
pubmed-meshheading:15629043-Models, Genetic,
pubmed-meshheading:15629043-Molecular Sequence Data,
pubmed-meshheading:15629043-Multiple Myeloma,
pubmed-meshheading:15629043-Phylogeny,
pubmed-meshheading:15629043-Pseudogenes,
pubmed-meshheading:15629043-RNA-Binding Proteins,
pubmed-meshheading:15629043-Sequence Alignment,
pubmed-meshheading:15629043-Sequence Analysis, DNA
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
The structure, expression and function prediction of DAZAP2, a down-regulated gene in multiple myeloma.
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| pubmed:publicationType |
Letter,
Comparative Study,
Research Support, Non-U.S. Gov't
|