Source:http://linkedlifedata.com/resource/pubmed/id/15629021
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2005-1-4
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| pubmed:abstractText |
Some 25 years ago it was found that parts of CNS could produce strong analgesic response on little morphine quantities. Later studies proved the existence for dozen of morphine-like substances, called opioids, which are normally produced in the brain. The most important are endorphins, met- and leu-encephalin and dinorphin produced both in hypothalamus and pituitary gland. The aim of our study was to found whether and how strong produce of beta-endorphins is to be expected when psychotropic drugs are used. Trazodon as antidepressant was used, and RIA technique for quantification of sera beta-endorphins. The results showed significant difference in rat sera beta-endorphins between certain days of drug application. These studies showed that beta-endorphins could be of great importance, used as markers for evaluation of patient treatment and eventual abuse of psychotropic drugs.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
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| pubmed:issn |
1512-8601
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
4
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
33-6
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| pubmed:meshHeading | |
| pubmed:year |
2004
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| pubmed:articleTitle |
Trazodone influence on rat sera beta-endorphins level.
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| pubmed:affiliation |
Institute for Physiology and Biochemistry, University of Sarajevo, Medical faculty, Bosnia and Herzegovina.
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| pubmed:publicationType |
Journal Article
|