Linked Life Data

15627807

Source:http://linkedlifedata.com/resource/pubmed/id/15627807

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2005-2-15
pubmed:abstractText
Increasing focus is being given to identify possible combinations of genes related to specific clinical phenotypes. In our sample of 814 patients comprising 114 with schizophrenia, 416 with bipolar affective disorder and 284 with unipolar affective disorder, we studied interactions between the tryptophan hydroxylase (TPH), the serotonin transporter (5-HTTLPR), and the dopamine receptor (DRD4) genes in relation to five major psychiatric symptomatology scores. There was significant interaction between the TPH and the 5-HTTLPR genes. With an increasing number of short (s) alleles of 5-HTTLPR, the scores for delusions, disorganization and negative symptoms were significantly decreasing among subjects having the TPH genotype AA but increasing among subjects having the TPH genotype AC, yielding the highest scores for the combinations AA x ll and AC x ss. Since high scores on just delusions, disorganization and negative symptoms but low scores on excitement and depression were found among subjects with schizophrenia, we conducted comparisons among the three diagnostic categories and controls as regards the combined TPH x 5-HTTLPR genotype distribution. Schizophrenia subjects had a significantly different distribution of the genotype combination for TPH x 5-HTTLPR as compared to 241 controls or to unipolar or bipolar subjects, and had significantly higher frequencies of AA x ll and of AC x ss. Thus, an interaction between TPH and 5-HTTLPR genes constitutes susceptibility to schizophrenia, thereby yielding apparent relationships between the major psychiatric symptomatology scores and genotype combinations in samples that are obtained by pooling schizophrenia with other diagnostic categories.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0302-282X
pubmed:author
pubmed:issnType
Print
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:15627807-Adult, pubmed-meshheading:15627807-Alleles, pubmed-meshheading:15627807-Chi-Square Distribution, pubmed-meshheading:15627807-Female, pubmed-meshheading:15627807-Genetic Predisposition to Disease, pubmed-meshheading:15627807-Genotype, pubmed-meshheading:15627807-Humans, pubmed-meshheading:15627807-Male, pubmed-meshheading:15627807-Membrane Glycoproteins, pubmed-meshheading:15627807-Membrane Transport Proteins, pubmed-meshheading:15627807-Middle Aged, pubmed-meshheading:15627807-Mood Disorders, pubmed-meshheading:15627807-Nerve Tissue Proteins, pubmed-meshheading:15627807-Polymorphism, Genetic, pubmed-meshheading:15627807-Psychiatric Status Rating Scales, pubmed-meshheading:15627807-Receptors, Dopamine D2, pubmed-meshheading:15627807-Receptors, Dopamine D4, pubmed-meshheading:15627807-Schizophrenia, pubmed-meshheading:15627807-Serotonin Plasma Membrane Transport Proteins, pubmed-meshheading:15627807-Tryptophan Hydroxylase
pubmed:year
2005
pubmed:articleTitle
Interaction between the tryptophan hydroxylase gene and the serotonin transporter gene in schizophrenia but not in bipolar or unipolar affective disorders.
pubmed:affiliation
Division of Psychiatry, Department of Clinical Sciences, University of Umeå, Umeå, Sweden. jayanti.chotai@vll.se
pubmed:publicationType
Journal Article, Comparative Study