Linked Life Data

15622730

Source:http://linkedlifedata.com/resource/pubmed/id/15622730

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2004-12-29
pubmed:abstractText
Neurotoxicity in the mouse was produced following oral administration of chlordecone at 10, 25 and 50 mg/kg/day in corn oil vehicle. Hyperexcitability and tremors were observed on the 1st, 4th and 9th day after the administration of chlordecone at 50, 25 and 10 mg/kg/day, respectively, and mortality occurred on the 5th, 7th and 13th day after daily administration of the respective doses. In all cases, the cumulative LD 50 for chlordecone was estimated between 180 and 200 mg/kg. Daily oral administration of chlordecone caused loss of body weight, and the loss of body weight was greatest at the onset of tremor. The effect of chlordecone on food and water consumption varied depending on the dose. A recovery in body weight, and food and water consumption were observed upon the termination of chlordecone treatment. In terms of neurotoxic responses, the effect of chlordecone on motor coordination in the mouse was dose-dependent, both during treatment and during recovery after terminating treatment. The threshold for pentylenetetrazol-induced seizures was significantly reduced in chlordecone treated animals. This study may provide essential basic information for studying the biochemical mechanisms of chlordecone-induced neurotoxicity in the mouse.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0161-813X
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
113-24
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Assessment of neurotoxicity induced by oral administration of chlordecone (Kepone) in the mouse.
pubmed:affiliation
Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS 39216, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.