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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7020
pubmed:dateCreated
2004-12-23
pubmed:databankReference
pubmed:abstractText
Human chromosome 16 features one of the highest levels of segmentally duplicated sequence among the human autosomes. We report here the 78,884,754 base pairs of finished chromosome 16 sequence, representing over 99.9% of its euchromatin. Manual annotation revealed 880 protein-coding genes confirmed by 1,670 aligned transcripts, 19 transfer RNA genes, 341 pseudogenes and three RNA pseudogenes. These genes include metallothionein, cadherin and iroquois gene families, as well as the disease genes for polycystic kidney disease and acute myelomonocytic leukaemia. Several large-scale structural polymorphisms spanning hundreds of kilobase pairs were identified and result in gene content differences among humans. Whereas the segmental duplications of chromosome 16 are enriched in the relatively gene-poor pericentromere of the p arm, some are involved in recent gene duplication and conversion events that are likely to have had an impact on the evolution of primates and human disease susceptibility.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1476-4687
pubmed:author
pubmed-author:FryI JIJ, pubmed-author:ManoharChitra FCF, pubmed-author:EichlerEvan EEE, pubmed-author:GradyDeborah LDL, pubmed-author:MoyzisRobert KRK, pubmed-author:RubinEdward MEM, pubmed-author:XieGaryG, pubmed-author:RichardsonPaulP, pubmed-author:BruceDavidD, pubmed-author:CallenDavid FDF, pubmed-author:MyersRichard MRM, pubmed-author:DetterJohn CJC, pubmed-author:RobinsonDonna LDL, pubmed-author:KimballHeatherH, pubmed-author:RashSamS, pubmed-author:PredkiPaulP, pubmed-author:HawkinsTrevorT, pubmed-author:DoggettNorman ANA, pubmed-author:ThompsonLinda SLS, pubmed-author:StallingsRaymond LRL, pubmed-author:DuncanScottS, pubmed-author:PennacchioLen ALA, pubmed-author:BranscombElbertE, pubmed-author:MartinJoelJ, pubmed-author:SchmutzJeremyJ, pubmed-author:CouronneOlivierO, pubmed-author:GrimwoodJaneJ, pubmed-author:HuangWayneW, pubmed-author:TerryAstridA, pubmed-author:GlavinaTijanaT, pubmed-author:RokhsarDaniel SDS, pubmed-author:ChertkovOlgaO, pubmed-author:LucasSusan MSM, pubmed-author:LouYunianY, pubmed-author:CaoileChenierC, pubmed-author:DicksonMarkM, pubmed-author:WhiteP ScottPS, pubmed-author:RodriguezAlexA, pubmed-author:KadnerKristenK, pubmed-author:AertsAndreaA, pubmed-author:LongmireJonathan LJL, pubmed-author:BrownNancy CNC, pubmed-author:WuJung-RungJR, pubmed-author:SheXinweiX, pubmed-author:MorganJennaJ, pubmed-author:JettJamieJ, pubmed-author:GordonLaurie ALA, pubmed-author:HellstenUffeU, pubmed-author:GoodsteinDavidD, pubmed-author:Tran-GyamfiMaryM, pubmed-author:AltherrMichaelM, pubmed-author:BajorekEvaE, pubmed-author:BlackStaceyS, pubmed-author:ChanYee ManYM, pubmed-author:ChristensenMariM, pubmed-author:DenysMirianM, pubmed-author:EscobarJulioJ, pubmed-author:FlowersDaveD, pubmed-author:FotopulosDeaD, pubmed-author:GomezMariaM, pubmed-author:GonzalesEidelynE, pubmed-author:GrozaMatthewM, pubmed-author:HammonNancyN, pubmed-author:HayduLaurenL, pubmed-author:IsraniSanjayS, pubmed-author:KobayashiArthurA, pubmed-author:LopezFrederickF, pubmed-author:LowrySteveS, pubmed-author:PitluckSamS, pubmed-author:PollardMartinM, pubmed-author:RamirezLuciaL, pubmed-author:RettererJamesJ, pubmed-author:SalamovAsafA, pubmed-author:ThayerNinaN, pubmed-author:TiceHopeH, pubmed-author:TsaiMingM, pubmed-author:UstaszewskaAnnaA, pubmed-author:WuKevinK, pubmed-author:YangJoanJ, pubmed-author:CampbellMary LML, pubmed-author:ChallacombeJean FJF, pubmed-author:WillyPatricia JPJ, pubmed-author:BrunoWilliam JWJ, pubmed-author:PrabhakarShyamS
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