Linked Life Data

15614623

Source:http://linkedlifedata.com/resource/pubmed/id/15614623

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2004-12-22
pubmed:abstractText
Commotio cordis, mechanical induction of heart rhythm disturbances, including sudden cardiac death, in the absence of corresponding structural damage, has been reported with increasing frequency in young individuals participating in sporting activities. Recently, the electrophysiological changes during c. cordis have been attributed to mechano-electric feedback, and particularly, to the recruitment of stretch-activated ion channels. The underlying mechanisms, however, by which a mechanical impact results in ventricular fibrillation, remain unknown. This study employs a 3D realistic model of rabbit ventricular geometry and fiber orientation to elucidate the electrophysiological mechanisms involved in arrhythmia induction following acute mechanical stimulation of the heart. Impact effects are modeled through stretch-activated ion channel activation in a 3D region of the ventricles representing the impact profile. Both cation-nonselective and potassium-selective stretch-activated ion channels are recruited upon mechanical impact. The impact is administered at various coupling intervals following pacing at the apex. To aid in the interpretation of results, the effect of mechanical stimulation on single cell action potentials is also examined. The results demonstrate that the region of impact is characterized by different types of cellular responses, including generation of a new action potential, shortening, or lengthening of action potential duration. The impact induces sustained reentry only when (1) a new activation is elicited by mechanical stimulation (caused by activation of cation-nonselective stretch-activated ion channels), and (2) upon return to the original region of impact, this activation does not encounter an extension of action potential duration (prevented by activation of potassium-selective stretch-activated ion channels).
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1567-2379
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
679-86
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Induction of ventricular arrhythmias following mechanical impact: a simulation study in 3D.
pubmed:affiliation
Biomedical Engineering, Tulane University, New Orleans, LA 70118, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't