Linked Life Data

15599669

Source:http://linkedlifedata.com/resource/pubmed/id/15599669

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2004-12-15
pubmed:abstractText
Although epidemiologic studies have revealed that high plasma cholesterol or high homocysteine levels, as well as diabetes, hypertension and smoking are important risk factors for atherosclerotic vascular disease, the deleterious effects of these conditions can be delayed or significantly attenuated by therapeutic interventions. Since the population in the Western world is aging, advancing age itself became one of the most significant risk factors for the development of atherosclerosis. Atherosclerosis is a chronic inflammatory disease, however, the mechanisms by which advanced age per se promotes vascular inflammation are not well understood. In the present review the authors propose a model for age-related alterations in cytokine expression, increased oxidative stress and decreased bioavailability of NO that underlie a pro-inflammatory phenotype of aged vessels promoting the development of atherosclerosis in the elderly.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0340-9937
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
733-40
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Vascular inflammation in aging.
pubmed:affiliation
Department of Physiology, New York Medical College, Valhalla 10595, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural