Linked Life Data

15591841

Source:http://linkedlifedata.com/resource/pubmed/id/15591841

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2004-12-13
pubmed:abstractText
A vast array of gene polymorphisms have been described, and further discovery of these gene variants will continue as the human genome is defined. Therefore, selection of a single polymorphism to investigate in relation to disease evolution or outcome must be motivated by specific physiologic, pathophysiologic, or epidemiologic associations. A significant gene polymorphism may result in an alteration of protein function, or be associated with disease incidence or outcome. Prevalence of the polymorphism in the general population is of extreme importance, as it must be common enough to warrant interest in its clinical impact. The polymorphism of the gene encoding for the enzyme adenosine monophosphate deaminase 1 results in an abnormal protein necessary in skeletal muscle metabolism. While its physiologic effects are not completely understood, it has been associated with improved morbidity and mortality in patients with cardiovascular disease.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1527-5299
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
274-78; quiz 279-80
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:articleTitle
A polymorphism of the gene encoding AMPD1: clinical impact and proposed mechanisms in congestive heart failure.
pubmed:affiliation
Dorothy M. Davis Heart and Lung Research Institute and the Division of Cardiovascular Diseases, Ohio State University, Columbus, OH 43210, USA. binkley-1@medctr.osu.edu
pubmed:publicationType
Journal Article, Review