rdf:type |
|
lifeskim:mentions |
umls-concept:C0030685,
umls-concept:C0033371,
umls-concept:C0086418,
umls-concept:C0184511,
umls-concept:C0205314,
umls-concept:C0229535,
umls-concept:C0243071,
umls-concept:C0391871,
umls-concept:C0597357,
umls-concept:C0679622,
umls-concept:C0680255,
umls-concept:C0911014,
umls-concept:C1283071,
umls-concept:C1510827,
umls-concept:C1963578
|
pubmed:issue |
6
|
pubmed:dateCreated |
2004-12-13
|
pubmed:abstractText |
Ghrelin, a recently identified 28-amino acid peptide is a potent GH secretagogue (GHS) produced predominantly by the stomach. Ghrelin stimulates GH secretion through binding to the GHS receptor in the hypothalamus and pituitary. In addition to the GH-releasing action, ghrelin has been found to be a powerful orexigenic factor. To assess the direct in vitro effects of ghrelin on human pituitary hormone secretion we have produced a panel of novel ghrelin analogs (molecular weight, 3323-3384; human native ghrelin, 3371) with enhanced affinity for the human GHS receptor (IC(50) 0.38-1.09 nM; human ghrelin, 1.2-2.2 nM).
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Dec
|
pubmed:issn |
0804-4643
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
151
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
787-95
|
pubmed:dateRevised |
2007-11-15
|
pubmed:meshHeading |
pubmed-meshheading:15588247-Adenoma,
pubmed-meshheading:15588247-Cells, Cultured,
pubmed-meshheading:15588247-Ghrelin,
pubmed-meshheading:15588247-Human Growth Hormone,
pubmed-meshheading:15588247-Humans,
pubmed-meshheading:15588247-Ligands,
pubmed-meshheading:15588247-Peptide Hormones,
pubmed-meshheading:15588247-Pituitary Gland,
pubmed-meshheading:15588247-Pituitary Neoplasms,
pubmed-meshheading:15588247-Prolactin,
pubmed-meshheading:15588247-RNA,
pubmed-meshheading:15588247-Receptors, G-Protein-Coupled,
pubmed-meshheading:15588247-Receptors, Ghrelin,
pubmed-meshheading:15588247-Reverse Transcriptase Polymerase Chain Reaction
|
pubmed:year |
2004
|
pubmed:articleTitle |
Novel ghrelin analogs with improved affinity for the GH secretagogue receptor stimulate GH and prolactin release from human pituitary cells.
|
pubmed:affiliation |
Institute of Endocrinology, Chaim Sheba Medical Center, Tel-Hashomer 52621, Israel.
|
pubmed:publicationType |
Journal Article
|