| pubmed-article:15585832 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15585832 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:15585832 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:15585832 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:15585832 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:15585832 | lifeskim:mentions | umls-concept:C0546816 | lld:lifeskim |
| pubmed-article:15585832 | lifeskim:mentions | umls-concept:C1306235 | lld:lifeskim |
| pubmed-article:15585832 | lifeskim:mentions | umls-concept:C0920421 | lld:lifeskim |
| pubmed-article:15585832 | lifeskim:mentions | umls-concept:C1705822 | lld:lifeskim |
| pubmed-article:15585832 | lifeskim:mentions | umls-concept:C0348011 | lld:lifeskim |
| pubmed-article:15585832 | lifeskim:mentions | umls-concept:C0152060 | lld:lifeskim |
| pubmed-article:15585832 | lifeskim:mentions | umls-concept:C0205154 | lld:lifeskim |
| pubmed-article:15585832 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:15585832 | pubmed:dateCreated | 2004-12-8 | lld:pubmed |
| pubmed-article:15585832 | pubmed:abstractText | The lack of persistence of transferred autologous mature lymphocytes in humans has been a major limitation to the application of effective cell transfer therapies. The results of a pilot clinical trial in 13 patients with metastatic melanoma suggested that conditioning with nonmyeloablative chemotherapy before adoptive transfer of activated tumor-reactive T cells enhances tumor regression and increases the overall rates of objective clinical responses. The present report examines the relationship between T cell persistence and tumor regression through analysis of the TCR beta-chain V region gene products expressed in samples obtained from 25 patients treated with this protocol. Sequence analysis demonstrated that there was a significant correlation between tumor regression and the degree of persistence in peripheral blood of adoptively transferred T cell clones, suggesting that inadequate T cell persistence may represent a major factor limiting responses to adoptive immunotherapy. | lld:pubmed |
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| pubmed-article:15585832 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15585832 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15585832 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:15585832 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15585832 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:15585832 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:15585832 | pubmed:author | pubmed-author:RosenbergStev... | lld:pubmed |
| pubmed-article:15585832 | pubmed:author | pubmed-author:DudleyMark... | lld:pubmed |
| pubmed-article:15585832 | pubmed:author | pubmed-author:El-GamilMonaM | lld:pubmed |
| pubmed-article:15585832 | pubmed:author | pubmed-author:RobbinsPaul... | lld:pubmed |
| pubmed-article:15585832 | pubmed:author | pubmed-author:ZhouJuhuaJ | lld:pubmed |
| pubmed-article:15585832 | pubmed:author | pubmed-author:LiYong FYF | lld:pubmed |
| pubmed-article:15585832 | pubmed:author | pubmed-author:PowellDaniel... | lld:pubmed |
| pubmed-article:15585832 | pubmed:author | pubmed-author:HuangJianping... | lld:pubmed |
| pubmed-article:15585832 | pubmed:author | pubmed-author:WunderlichJoh... | lld:pubmed |
| pubmed-article:15585832 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15585832 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:15585832 | pubmed:volume | 173 | lld:pubmed |
| pubmed-article:15585832 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15585832 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15585832 | pubmed:pagination | 7125-30 | lld:pubmed |
| pubmed-article:15585832 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:15585832 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15585832 | pubmed:articleTitle | Cutting edge: persistence of transferred lymphocyte clonotypes correlates with cancer regression in patients receiving cell transfer therapy. | lld:pubmed |
| pubmed-article:15585832 | pubmed:affiliation | Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Paul_Robbins@nih.gov | lld:pubmed |
| pubmed-article:15585832 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15585832 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:15585832 | pubmed:publicationType | Comparative Study | lld:pubmed |
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