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rdf:type |
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lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0024264,
umls-concept:C0030705,
umls-concept:C0087111,
umls-concept:C0152060,
umls-concept:C0205154,
umls-concept:C0348011,
umls-concept:C0546816,
umls-concept:C0920421,
umls-concept:C1306235,
umls-concept:C1705822
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pubmed:issue |
12
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pubmed:dateCreated |
2004-12-8
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pubmed:abstractText |
The lack of persistence of transferred autologous mature lymphocytes in humans has been a major limitation to the application of effective cell transfer therapies. The results of a pilot clinical trial in 13 patients with metastatic melanoma suggested that conditioning with nonmyeloablative chemotherapy before adoptive transfer of activated tumor-reactive T cells enhances tumor regression and increases the overall rates of objective clinical responses. The present report examines the relationship between T cell persistence and tumor regression through analysis of the TCR beta-chain V region gene products expressed in samples obtained from 25 patients treated with this protocol. Sequence analysis demonstrated that there was a significant correlation between tumor regression and the degree of persistence in peripheral blood of adoptively transferred T cell clones, suggesting that inadequate T cell persistence may represent a major factor limiting responses to adoptive immunotherapy.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15585832-11342421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15585832-11565838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15585832-12000866,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15585832-12070280,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15585832-12242449,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15585832-12427970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15585832-12695490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15585832-14580882,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15585832-15128789,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15585832-1691237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15585832-2381442,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15585832-7706734,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15585832-8810254,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15585832-9278327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15585832-9405262
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
173
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7125-30
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:15585832-Cell Proliferation,
pubmed-meshheading:15585832-Cell Survival,
pubmed-meshheading:15585832-Clone Cells,
pubmed-meshheading:15585832-Gene Rearrangement, beta-Chain T-Cell Antigen Receptor,
pubmed-meshheading:15585832-Humans,
pubmed-meshheading:15585832-Immunoglobulin Variable Region,
pubmed-meshheading:15585832-Immunotherapy, Adoptive,
pubmed-meshheading:15585832-Lymphocyte Count,
pubmed-meshheading:15585832-Lymphocyte Transfusion,
pubmed-meshheading:15585832-Lymphocytes, Tumor-Infiltrating,
pubmed-meshheading:15585832-Melanoma,
pubmed-meshheading:15585832-Pilot Projects,
pubmed-meshheading:15585832-Receptors, Antigen, T-Cell, alpha-beta
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pubmed:year |
2004
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pubmed:articleTitle |
Cutting edge: persistence of transferred lymphocyte clonotypes correlates with cancer regression in patients receiving cell transfer therapy.
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pubmed:affiliation |
Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Paul_Robbins@nih.gov
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study
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