Linked Life Data

15583454

Source:http://linkedlifedata.com/resource/pubmed/id/15583454

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2004-12-7
pubmed:abstractText
Serious complications of hydroxyethyl starch (HES) administration have been repeatedly demonstrated in clinical trials of acute ischemic stroke and other brain injuries. Such complications have prompted the premature termination of several randomized trials. Coagulopathy and bleeding have been the most frequently documented complications in the brain injury setting and have occurred after exposure to HES solutions of widely varying molecular weight and substitutions. Severe, protracted, refractory pruritus is another HES complication. Claims of safety for HES solutions have often been made on the basis of small trials with inadequate statistical power. Additionally, the safety has been typically assessed in highly selected low-risk patient populations receiving relatively small HES doses, so that the results cannot be generalized to routine clinical practice. The preponderance of available evidence suggests that HES solutions should be avoided in acute ischemic stroke and other brain injuries.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1424-8832
pubmed:author
pubmed:copyrightInfo
Copyright 2004 S. Karger AG, Basel.
pubmed:issnType
Print
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
225-8; author reply 229-30
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:articleTitle
Complications of hydroxyethyl starch in acute ischemic stroke and other brain injuries.
pubmed:publicationType
Letter, Comment