Linked Life Data

15579016

Source:http://linkedlifedata.com/resource/pubmed/id/15579016

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2004-12-6
pubmed:abstractText
Natural and synthetic indolocarbazole compounds have triggered considerable interest since the discovery in 1986 of the inhibitory properties of staurosporine toward protein kinase C (PKC). Later, it has been shown that indolocarbazole compounds may inhibit various kinases, such as cyclin dependent-kinases and/or topoisomerase I, someones behave only as DNA intercalators. In this review are presented various indolocarbazole compounds bearing a sugar moiety and their biological targets. The relevance of these targets to develop indolocarbazole compounds as potential antitumor agents is discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1568-0118
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
509-21
pubmed:dateRevised
2006-1-20
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Biological targets of antitumor indolocarbazoles bearing a sugar moiety.
pubmed:affiliation
Laboratoire SEESIB, UMR 6504 CNRS, Université Blaise Pascal, 24, Avenue des Landais, 63177 Aubiere, France. mprud@chimie.univ-bpclermont.fr
pubmed:publicationType
Journal Article, Review