15569978

Source:http://linkedlifedata.com/resource/pubmed/id/15569978

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0001779, umls-concept:C0019186, umls-concept:C0042769, umls-concept:C0079399, umls-concept:C0332281, umls-concept:C1512554, umls-concept:C2239176, umls-concept:C2362057
pubmed:issue	22
pubmed:dateCreated	2004-11-30
pubmed:abstractText	The tumor suppressor gene p16INK4A is mainly inactivated by an epigenetic change involving promoter hypermethylation in hepatocarcinogenesis. The possible clinical impact of p16INK4A methylation and the potential risk factors for this epigenetic alteration have not been thoroughly investigated.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9502500
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor..., http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger
pubmed:status	MEDLINE
pubmed:month	Nov
pubmed:issn	1078-0432
pubmed:author	pubmed-author:GuidoTorzilliT, pubmed-author:HasegawaKiyoshiK, pubmed-author:HuiAi-MinAM, pubmed-author:MakuuchiMasatoshiM, pubmed-author:MinagawaMasamiM, pubmed-author:SunLinL, pubmed-author:TakayamaTadatoshiT, pubmed-author:XuZ CZC
pubmed:issnType	Print
pubmed:day	15
pubmed:volume	10
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	7484-9
pubmed:dateRevised	2005-11-17
pubmed:meshHeading	pubmed-meshheading:15569978-Adult, pubmed-meshheading:15569978-Age Factors, pubmed-meshheading:15569978-Aged, pubmed-meshheading:15569978-Carcinoma, Hepatocellular, pubmed-meshheading:15569978-Cyclin-Dependent Kinase Inhibitor p16, pubmed-meshheading:15569978-DNA Methylation, pubmed-meshheading:15569978-Disease-Free Survival, pubmed-meshheading:15569978-Female, pubmed-meshheading:15569978-Fibrosis, pubmed-meshheading:15569978-Hepatitis Viruses, pubmed-meshheading:15569978-Humans, pubmed-meshheading:15569978-Immunohistochemistry, pubmed-meshheading:15569978-Liver, pubmed-meshheading:15569978-Liver Neoplasms, pubmed-meshheading:15569978-Male, pubmed-meshheading:15569978-Middle Aged, pubmed-meshheading:15569978-Polymerase Chain Reaction, pubmed-meshheading:15569978-RNA, Messenger, pubmed-meshheading:15569978-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:15569978-Risk Factors, pubmed-meshheading:15569978-Sex Factors, pubmed-meshheading:15569978-Time Factors
pubmed:year	2004
pubmed:articleTitle	p16INK4A hypermethylation is associated with hepatitis virus infection, age, and gender in hepatocellular carcinoma.
pubmed:affiliation	Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.
pubmed:publicationType	Journal Article