Source:http://linkedlifedata.com/resource/pubmed/id/15569857
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2004-12-31
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| pubmed:abstractText |
S-nitrosoalbumin (SNO-Alb) is a major reservoir of releasable nitric oxide (NO) in plasma. In preeclampsia, a pregnancy-specific disorder associated with endothelial dysfunction, we previously found significant elevations in plasma SNO-Alb concentrations and decreased plasma ascorbate (Asc) levels. This increased SNO-Alb may result from low-plasma Asc if Asc, along with transition metals (eg, copper [Cu]) are necessary for release of NO from S-nitrosothiols. We propose that vasodilator effects of SNO-Alb, mediated by release of NO, are fully realized only when Asc/Cu availability is sufficient. Relaxation responses to SNO-Alb or the control reduced human serum albumin (SH-Alb), and responses to pooled plasma from normal or preeclamptic pregnancies were examined in isolated mouse arteries. Arteries preconstricted with phenylephrine were exposed to SNO-Alb or SH-Alb at physiologically relevant concentrations. When free Cu was added in excess (10 mumol/L), NO release was not dependent on Asc. However, when Cu was added at lower (physiological) levels, NO release was dependent on Asc. The addition of Asc and Cu to SNO-Alb stimulated vasodilatory responses in isolated arteries >90%, whereas no change in the SH-Alb (5%) response was observed. Preeclampsia plasma with higher levels of SNO-Alb caused arteries to relax 44.1+/-4.7%, whereas normal pregnancy plasma caused 11.9+/-4.2% relaxation (P=0.007). These data indicate that SNO-Alb alone or in plasma can act as a potent vasodilator, and that sufficient Asc/Cu promotes this action. We suggest that the higher circulating levels of SNO-Alb, in women with preeclampsia, reflect a deficiency in Asc/Cu-mediated release of NO from SNO-Alb.
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| pubmed:grant | |
| pubmed:commentsCorrections | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1H-(1,2,4)oxadiazolo(4,3-a)quinoxali...,
http://linkedlifedata.com/resource/pubmed/chemical/Ascorbic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Copper,
http://linkedlifedata.com/resource/pubmed/chemical/NG-Nitroarginine Methyl Ester,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Donors,
http://linkedlifedata.com/resource/pubmed/chemical/Nitroso Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Oxadiazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Phenylephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Quinoxalines,
http://linkedlifedata.com/resource/pubmed/chemical/S-nitrosoalbumin,
http://linkedlifedata.com/resource/pubmed/chemical/Serum Albumin, Bovine
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
1524-4563
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| pubmed:author |
pubmed-author:ArroyoAntonioA,
pubmed-author:DaftaryAshiA,
pubmed-author:GandleyRobin ERE,
pubmed-author:HargerGailG,
pubmed-author:HuangWanW,
pubmed-author:HubelCarl ACA,
pubmed-author:JiangJianfeiJ,
pubmed-author:KaganValerian EVE,
pubmed-author:PittBruceB,
pubmed-author:TaylorRobert NRN,
pubmed-author:TyurinVladimir AVA
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| pubmed:issnType |
Electronic
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| pubmed:volume |
45
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
21-7
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:15569857-Adult,
pubmed-meshheading:15569857-Animals,
pubmed-meshheading:15569857-Ascorbic Acid,
pubmed-meshheading:15569857-Copper,
pubmed-meshheading:15569857-Female,
pubmed-meshheading:15569857-Humans,
pubmed-meshheading:15569857-Mesenteric Arteries,
pubmed-meshheading:15569857-Mice,
pubmed-meshheading:15569857-NG-Nitroarginine Methyl Ester,
pubmed-meshheading:15569857-Nitric Oxide,
pubmed-meshheading:15569857-Nitric Oxide Donors,
pubmed-meshheading:15569857-Nitroso Compounds,
pubmed-meshheading:15569857-Oxadiazoles,
pubmed-meshheading:15569857-Oxidative Stress,
pubmed-meshheading:15569857-Phenylephrine,
pubmed-meshheading:15569857-Pre-Eclampsia,
pubmed-meshheading:15569857-Pregnancy,
pubmed-meshheading:15569857-Quinoxalines,
pubmed-meshheading:15569857-Serum Albumin, Bovine,
pubmed-meshheading:15569857-Vasodilation
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| pubmed:year |
2005
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| pubmed:articleTitle |
S-nitrosoalbumin-mediated relaxation is enhanced by ascorbate and copper: effects in pregnancy and preeclampsia plasma.
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| pubmed:affiliation |
Magee-Womens Research Institute and Department of Environmental and Occupational Health, University of Pittsburgh, 204 Craft Ave, Pittsburgh, PA 15213, USA. rsireg@mwri.magee.edu
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, N.I.H., Extramural
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