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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
1992-5-5
|
| pubmed:abstractText |
Estrogens are potent mammary tumor promoters influencing post-initiation events via epigenetic mechanisms. The upregulation (i.e., induction) of the C16 alpha-hydroxylation pathway during 17 beta-estradiol (E2) biotransformation has been associated with mammary cell transformation. The action of E2 metabolites on tumorigenic transformation, however, is poorly understood.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0027-8874
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
84
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
634-8
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:1556774-Animals,
pubmed-meshheading:1556774-Cell Division,
pubmed-meshheading:1556774-Cell Transformation, Neoplastic,
pubmed-meshheading:1556774-DNA Repair,
pubmed-meshheading:1556774-Estradiol,
pubmed-meshheading:1556774-Female,
pubmed-meshheading:1556774-Hydroxyestrones,
pubmed-meshheading:1556774-Mammary Neoplasms, Experimental,
pubmed-meshheading:1556774-Mice,
pubmed-meshheading:1556774-Mice, Inbred C57BL,
pubmed-meshheading:1556774-Tumor Cells, Cultured
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Induction by estrogen metabolite 16 alpha-hydroxyestrone of genotoxic damage and aberrant proliferation in mouse mammary epithelial cells.
|
| pubmed:affiliation |
Breast Cancer Research Laboratory, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|