Linked Life Data

15560715

Source:http://linkedlifedata.com/resource/pubmed/id/15560715

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2004-11-24
pubmed:abstractText
Despite multiple advances in medical imaging, noninvasive monitoring of therapeutic efficacy for malignant gliomas remains problematic. An underutilized observation is that malignancy induces characteristic abnormalities of vessel shape. These characteristic shape abnormalities affect both capillaries and much larger vessels in the tumor vicinity, involve larger vessels prior to sprout formation, and are generally not present in hypervascular benign tumors. Vessel shape abnormalities associated with malignancy thus may appear independently of increase in vessel density. We hypothesize that an automated, computerized analysis of vessel shape as defined from high-resolution MRA can provide valuable information about tumor activity during the treatment of malignant gliomas. This report describes vessel shape properties in 10 malignant gliomas prior to treatment, in 2 patients in remission during treatment, and in 2 patients with recurrent disease. One subject was scanned multiple times. The method involves an automated, statistical analysis of vessel shape within a region of interest for each tumor, normalized by the values obtained from the vessels within the same region of interest of 34 healthy subjects. Results indicate that untreated tumors display statistically significant vessel tortuosity abnormalities. These abnormalities involve vessels not only within the tumor margins as defined from MR but also vessels in the surrounding tissue. The abnormalities resolve during effective treatment and recur with tumor recurrence. We conclude that vessel shape analysis could provide an important means of assessing tumor activity.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/15560715-10549491, http://linkedlifedata.com/resource/pubmed/commentcorrection/15560715-10639502, http://linkedlifedata.com/resource/pubmed/commentcorrection/15560715-10639516, http://linkedlifedata.com/resource/pubmed/commentcorrection/15560715-10850285, http://linkedlifedata.com/resource/pubmed/commentcorrection/15560715-10919633, http://linkedlifedata.com/resource/pubmed/commentcorrection/15560715-11297244, http://linkedlifedata.com/resource/pubmed/commentcorrection/15560715-11516709, http://linkedlifedata.com/resource/pubmed/commentcorrection/15560715-11948144, http://linkedlifedata.com/resource/pubmed/commentcorrection/15560715-12756647, http://linkedlifedata.com/resource/pubmed/commentcorrection/15560715-14607296, http://linkedlifedata.com/resource/pubmed/commentcorrection/15560715-14625221, http://linkedlifedata.com/resource/pubmed/commentcorrection/15560715-14697002, http://linkedlifedata.com/resource/pubmed/commentcorrection/15560715-15140713, http://linkedlifedata.com/resource/pubmed/commentcorrection/15560715-15275923
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1533-0346
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
577-84
pubmed:dateRevised
2011-9-26
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Abnormal vessel tortuosity as a marker of treatment response of malignant gliomas: preliminary report.
pubmed:affiliation
Department of Surgery, University of North Carolina, 349 Wing C, CB #7062, Chapel Hill, NC 27599, USA. bullitt@med.unc.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.