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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1992-5-7
|
| pubmed:abstractText |
Between 1971 and 1985, 598 patients with ovarian carcinoma were treated with abdomino-pelvic radiation therapy. Acute complications included nausea and vomiting in 364 patients (61%) which were severe in 36, and diarrhea in 407 patients (68%), severe in 35. Leukopenia (less than 2.0 x 10(9) cells/liter) and thrombocytopenia (less than 100 x 10(9) cells/liter) occurred in 64 patients (11%) each. Treatment interruptions occurred in 136 patients (23%), and 62 patients (10%) did not complete treatment. In both situations the most common cause was myelosuppression. Late complications included chronic diarrhea in 85 patients (14%), transient hepatic enzyme elevation in 224 (44%), and symptomatic basal pneumonitis in 23 (4%). Serious late bowel complications were infrequent: 25 patients (4.2%) developed bowel obstruction and 16 required operation. Multivariate analysis was unable to determine any significant prognostic factors for bowel obstruction; however, the moving-strip technique of radiation therapy was associated with a significantly greater risk of developing chronic diarrhea, pneumonitis, and hepatic enzyme elevation than was the open beam technique. We conclude that abdomino-pelvic radiation therapy as used in these patients is associated with modest acute complications and a low risk of serious late toxicity.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0360-3016
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
22
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
847-51
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:1555975-Abdomen,
pubmed-meshheading:1555975-Adult,
pubmed-meshheading:1555975-Aged,
pubmed-meshheading:1555975-Aged, 80 and over,
pubmed-meshheading:1555975-Canada,
pubmed-meshheading:1555975-Female,
pubmed-meshheading:1555975-Humans,
pubmed-meshheading:1555975-Middle Aged,
pubmed-meshheading:1555975-Ovarian Neoplasms,
pubmed-meshheading:1555975-Pelvis,
pubmed-meshheading:1555975-Prospective Studies,
pubmed-meshheading:1555975-Radiotherapy
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Analysis of complications in patients treated with abdomino-pelvic radiation therapy for ovarian carcinoma.
|
| pubmed:affiliation |
Department of Radiation Oncology, Princess Margaret Hospital, Toronto, Canada.
|
| pubmed:publicationType |
Journal Article
|