Source:http://linkedlifedata.com/resource/pubmed/id/15556756
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
24
|
| pubmed:dateCreated |
2004-11-23
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| pubmed:abstractText |
Two thia-DCK analogs (3a,b) were synthesized and evaluated for inhibition of HIV-1 replication in H9 lymphocytes. Compound 3a showed potent anti-HIV activity with an EC50 value of 0.14 microM and a therapeutic index of 1110. However, the corresponding 6-tert-butyl-substituted compound (3b) showed no suppression. The bioassay results indicated that thia-DCK analogs merit attention as potential HIV-1 inhibitors.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0968-0896
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
12
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
6383-7
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:15556756-Anti-HIV Agents,
pubmed-meshheading:15556756-Cell Line,
pubmed-meshheading:15556756-HIV,
pubmed-meshheading:15556756-Humans,
pubmed-meshheading:15556756-Inhibitory Concentration 50,
pubmed-meshheading:15556756-Lactones,
pubmed-meshheading:15556756-Lymphocytes,
pubmed-meshheading:15556756-Structure-Activity Relationship,
pubmed-meshheading:15556756-Thiones
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
Anti-AIDS agents. Part 56: Synthesis and anti-HIV activity of 7-thia-di-O-(-)-camphanoyl-(+)-cis-khellactone (7-thia-DCK) analogs.
|
| pubmed:affiliation |
Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 200032, China.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|