| pubmed-article:15554928 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15554928 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:15554928 | lifeskim:mentions | umls-concept:C0205252 | lld:lifeskim |
| pubmed-article:15554928 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:15554928 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:15554928 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:15554928 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:15554928 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:15554928 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:15554928 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:15554928 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:15554928 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:15554928 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:15554928 | pubmed:dateCreated | 2004-11-23 | lld:pubmed |
| pubmed-article:15554928 | pubmed:abstractText | Regulatory T (Treg) cells, derived from co-cultures of unfractionated CD4(+) T cells and immature dendritic cells (DC), suppress enteroantigen-induced proliferation of CD4(+) CD25(-) T cells. The DC-induced Treg cells are a mixture of CD25(+) (10-20%) and CD25(-) (80-90%) T cells. However, all the suppressor activity in vitro and in vivo resides in the CD25(+) T-cell subset. The CD25(+) DC-induced Treg cells can inhibit enteroantigen-induced proliferation in vitro through a transwell membrane, and their function does not appear to depend on previous activation. DC-induced CD25(+) Treg cells display a naive phenotype, expressing high levels of CD45RB and l-selectin (CD62L). In addition, the DC-induced Treg cells mediate a stronger suppressive activity than prototype CD25(+) regulatory T cells. The DC-induced Treg cells, and hereof purified CD25(+) and CD25(-) T-cell fractions, were co-injected into severe combined immunodeficiency (SCID) mice with colitis-inducing CD4(+) CD25(-) T cells. Both unfractionated CD4(+) and purified CD25(+) Treg cells fully protected the recipients against the development of colitis. In contrast, co-transfer of fractionated CD25(-) T cells offered no protection against disease development. Enterobacterial antigen-exposed CD4(+) T cells of the protected mice secreted higher levels of interleukin-10 and lower levels of interferon-gamma than the unprotected mice. The present data demonstrate DC-induced CD4(+) CD25(+) Treg cells, which phenotypically and functionally differ from the generally accepted prototype of CD25(+) Treg cells. These data may initiate new procedures for the expansion of Treg cells for clinical use. | lld:pubmed |
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| pubmed-article:15554928 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15554928 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15554928 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15554928 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15554928 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:15554928 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:15554928 | pubmed:author | pubmed-author:KuryEvelynE | lld:pubmed |
| pubmed-article:15554928 | pubmed:author | pubmed-author:ClaessonMogen... | lld:pubmed |
| pubmed-article:15554928 | pubmed:author | pubmed-author:KristensenNan... | lld:pubmed |
| pubmed-article:15554928 | pubmed:author | pubmed-author:GadMonikaM | lld:pubmed |
| pubmed-article:15554928 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15554928 | pubmed:volume | 113 | lld:pubmed |
| pubmed-article:15554928 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15554928 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15554928 | pubmed:pagination | 499-508 | lld:pubmed |
| pubmed-article:15554928 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:15554928 | pubmed:meshHeading | pubmed-meshheading:15554928... | lld:pubmed |
| pubmed-article:15554928 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15554928 | pubmed:articleTitle | Characterization of T-regulatory cells, induced by immature dendritic cells, which inhibit enteroantigen-reactive colitis-inducing T-cell responses in vitro and in vivo. | lld:pubmed |
| pubmed-article:15554928 | pubmed:affiliation | Laboratory of Experimental Immunology, Department of Medical Anatomy, The Panum Institute, University of Copenhagen, Copenhagen, Denmark. m.gad@mami.ku.dk | lld:pubmed |
| pubmed-article:15554928 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15554928 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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