rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
11
|
pubmed:dateCreated |
2004-11-19
|
pubmed:abstractText |
Peritoneal metastasis is the most frequent form of recurrence for advanced gastric cancer. We previously performed a global analysis of the gene expression of gastric cancer cell lines established from peritoneal metastasis with cDNA microarray. One of the up-regulated genes is L-3 phosphoserine phosphatase (L3-PP). We have examined its potential as a novel marker for the detection of peritoneal micrometastasis of gastric cancer. L3-PP mRNA in peritoneal wash in 93 gastric cancer patients was quantified for comparison of carcinoembryonic antigen (CEA) mRNA by means of real-time RT-PCR to predict peritoneal recurrence. The quantity of L3-PP and CEA correlated with wall penetration. Eleven out of 18 cases with peritoneal dissemination were L3-PP+ (61% sensitivity). For three out of 18 cases of peritoneal dissemination, only L3-PP could detect micrometastasis of gastric cancer. Consequently, free cancer cells that cannot be detected by CEA mRNA could be detected using L3-PP mRNA. Although CEA alone was not sufficient, L3-PP and CEA in combination can attain a higher accuracy of detection.
|
pubmed:language |
jpn
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0385-0684
|
pubmed:author |
pubmed-author:HagiwaraAkeoA,
pubmed-author:IizukaRyoujiR,
pubmed-author:IkawaWataruW,
pubmed-author:KakiharaNaokiN,
pubmed-author:MatsumuraHiroomiH,
pubmed-author:MiyataKeigoK,
pubmed-author:OhgakiMasaharuM,
pubmed-author:SakakuraChouheiC,
pubmed-author:ShimomuraKatsumiK,
pubmed-author:ShimotsumaMasatakaM,
pubmed-author:TakenakaAtsushiA,
pubmed-author:YamagishiHisakazuH
|
pubmed:issnType |
Print
|
pubmed:volume |
31
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1912-4
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:15553757-Aged,
pubmed-meshheading:15553757-Aged, 80 and over,
pubmed-meshheading:15553757-Carcinoembryonic Antigen,
pubmed-meshheading:15553757-Cell Line, Tumor,
pubmed-meshheading:15553757-Female,
pubmed-meshheading:15553757-Gene Expression,
pubmed-meshheading:15553757-Genetic Markers,
pubmed-meshheading:15553757-Humans,
pubmed-meshheading:15553757-Male,
pubmed-meshheading:15553757-Middle Aged,
pubmed-meshheading:15553757-Peritoneal Neoplasms,
pubmed-meshheading:15553757-Phosphoric Monoester Hydrolases,
pubmed-meshheading:15553757-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15553757-Sensitivity and Specificity,
pubmed-meshheading:15553757-Stomach Neoplasms,
pubmed-meshheading:15553757-Tumor Markers, Biological
|
pubmed:year |
2004
|
pubmed:articleTitle |
[Nobel genes improve accuracy in detection of peritoneal micro-metastasis of gastric cancer to decide indication for chemotherapy].
|
pubmed:affiliation |
Dept of Surgery, Kyoto Second Red-Cross Hospital.
|
pubmed:publicationType |
Journal Article,
Comparative Study,
English Abstract
|