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pubmed-article:15545865pubmed:abstractTextTo assess prevalence of nelfinavir resistance mutations in children receiving highly active antiretroviral therapy, sequencing of protease gene from plasma of 53 human immunodeficiency virus-infected children was performed. The prevalence of L90M was similar to that of D30N. There was a significant correlation with a higher viral load and lower age and the occurrence of L90M. These findings suggest differential molecular age- and viral load-related routes for nelfinavir resistance.lld:pubmed
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pubmed-article:15545865pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:15545865pubmed:articleTitleAlternative, age- and viral load-related routes of nelfinavir resistance in human immunodeficiency virus type 1-infected children receiving highly active antiretroviral therapy.lld:pubmed
pubmed-article:15545865pubmed:affiliationServiço de Doenças Infecciosas e Parasitárias, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, RJ, Brazil. emachado@biologia.ufrj.brlld:pubmed
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