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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2004-11-16
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pubmed:abstractText |
To assess prevalence of nelfinavir resistance mutations in children receiving highly active antiretroviral therapy, sequencing of protease gene from plasma of 53 human immunodeficiency virus-infected children was performed. The prevalence of L90M was similar to that of D30N. There was a significant correlation with a higher viral load and lower age and the occurrence of L90M. These findings suggest differential molecular age- and viral load-related routes for nelfinavir resistance.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0891-3668
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1057-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15545865-Age Factors,
pubmed-meshheading:15545865-Antiretroviral Therapy, Highly Active,
pubmed-meshheading:15545865-Child,
pubmed-meshheading:15545865-Child, Preschool,
pubmed-meshheading:15545865-Cohort Studies,
pubmed-meshheading:15545865-Drug Resistance, Viral,
pubmed-meshheading:15545865-Female,
pubmed-meshheading:15545865-HIV Infections,
pubmed-meshheading:15545865-HIV-1,
pubmed-meshheading:15545865-Humans,
pubmed-meshheading:15545865-Male,
pubmed-meshheading:15545865-Microbial Sensitivity Tests,
pubmed-meshheading:15545865-Mutation,
pubmed-meshheading:15545865-Nelfinavir,
pubmed-meshheading:15545865-Pharmacogenetics,
pubmed-meshheading:15545865-Risk Factors,
pubmed-meshheading:15545865-Sampling Studies,
pubmed-meshheading:15545865-Sensitivity and Specificity,
pubmed-meshheading:15545865-Viral Load
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pubmed:year |
2004
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pubmed:articleTitle |
Alternative, age- and viral load-related routes of nelfinavir resistance in human immunodeficiency virus type 1-infected children receiving highly active antiretroviral therapy.
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pubmed:affiliation |
Serviço de Doenças Infecciosas e Parasitárias, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, RJ, Brazil. emachado@biologia.ufrj.br
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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