Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2005-2-7
pubmed:abstractText
Prostaglandin E2 (PGE2) can stimulate tumor progression by modulating several proneoplastic pathways, including proliferation, angiogenesis, cell migration, invasion, and apoptosis. Although steady-state tissue levels of PGE2 stem from relative rates of biosynthesis and breakdown, most reports examining PGE2 have focused solely on the cyclooxygenase-dependent formation of this bioactive lipid. Enzymatic degradation of PGE2 involves the NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH). The present study examined a range of normal tissues in the human and mouse and found high levels of 15-PGDH in the large intestine. By contrast, the expression of 15-PGDH is decreased in several colorectal carcinoma cell lines and in other human malignancies such as breast and lung carcinomas. Consistent with these findings, we observe diminished 15-Pgdh expression in ApcMin+/- mouse adenomas. Enzymatic activity of 15-PGDH correlates with expression levels and the genetic disruption of 15-Pgdh completely blocks production of the urinary PGE2 metabolite. Finally, 15-PGDH expression and activity are significantly down-regulated in human colorectal carcinomas relative to matched normal tissue. In summary, these results suggest a novel tumor suppressive role for 15-PGDH due to loss of expression during colorectal tumor progression.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/15542609-10686540, http://linkedlifedata.com/resource/pubmed/commentcorrection/15542609-11006085, http://linkedlifedata.com/resource/pubmed/commentcorrection/15542609-11278747, http://linkedlifedata.com/resource/pubmed/commentcorrection/15542609-11477553, http://linkedlifedata.com/resource/pubmed/commentcorrection/15542609-11821873, http://linkedlifedata.com/resource/pubmed/commentcorrection/15542609-11875501, http://linkedlifedata.com/resource/pubmed/commentcorrection/15542609-12220539, http://linkedlifedata.com/resource/pubmed/commentcorrection/15542609-12559775, http://linkedlifedata.com/resource/pubmed/commentcorrection/15542609-12795052, http://linkedlifedata.com/resource/pubmed/commentcorrection/15542609-12824187, http://linkedlifedata.com/resource/pubmed/commentcorrection/15542609-12914529, http://linkedlifedata.com/resource/pubmed/commentcorrection/15542609-12941845, http://linkedlifedata.com/resource/pubmed/commentcorrection/15542609-12954496, http://linkedlifedata.com/resource/pubmed/commentcorrection/15542609-14522879, http://linkedlifedata.com/resource/pubmed/commentcorrection/15542609-14633712, http://linkedlifedata.com/resource/pubmed/commentcorrection/15542609-14706341, http://linkedlifedata.com/resource/pubmed/commentcorrection/15542609-14736730, http://linkedlifedata.com/resource/pubmed/commentcorrection/15542609-14742435, http://linkedlifedata.com/resource/pubmed/commentcorrection/15542609-14749354, http://linkedlifedata.com/resource/pubmed/commentcorrection/15542609-14762779, http://linkedlifedata.com/resource/pubmed/commentcorrection/15542609-14977603, http://linkedlifedata.com/resource/pubmed/commentcorrection/15542609-15269313, http://linkedlifedata.com/resource/pubmed/commentcorrection/15542609-15294912, http://linkedlifedata.com/resource/pubmed/commentcorrection/15542609-15380519, http://linkedlifedata.com/resource/pubmed/commentcorrection/15542609-15494133, http://linkedlifedata.com/resource/pubmed/commentcorrection/15542609-184819, http://linkedlifedata.com/resource/pubmed/commentcorrection/15542609-7612182, http://linkedlifedata.com/resource/pubmed/commentcorrection/15542609-8095852, http://linkedlifedata.com/resource/pubmed/commentcorrection/15542609-8200564, http://linkedlifedata.com/resource/pubmed/commentcorrection/15542609-8203528, http://linkedlifedata.com/resource/pubmed/commentcorrection/15542609-8228569, http://linkedlifedata.com/resource/pubmed/commentcorrection/15542609-9048936, http://linkedlifedata.com/resource/pubmed/commentcorrection/15542609-9288778, http://linkedlifedata.com/resource/pubmed/commentcorrection/15542609-9443418, http://linkedlifedata.com/resource/pubmed/commentcorrection/15542609-9677101, http://linkedlifedata.com/resource/pubmed/commentcorrection/15542609-9927187
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0021-9258
pubmed:author
pubmed:issnType
Print
pubmed:day
4
pubmed:volume
280
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3217-23
pubmed:dateRevised
2011-5-25
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
15-Hydroxyprostaglandin dehydrogenase is down-regulated in colorectal cancer.
pubmed:affiliation
Department of Medicine, Cell and Developmental Biology, Vanderbilt University Medical Center and the Vanderbilt-Ingram Cancer Center, Nashville, Tennessee 37232-6838, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't