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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6-7
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pubmed:dateCreated |
2004-11-15
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pubmed:abstractText |
A longitudinal study was undertaken in Burkina Faso among 293 children aged 6 months to 9 years in order to determine the correlation between an antibody response to several individual malarial antigens and malarial infection. It was found that the presence of a positive antibody response at the beginning of the rainy season to three long synthetic peptides corresponding to Plasmodium falciparum Exp-1 101-162, MSP-3 154-249 and GLURP 801-920 but not to CSP 274-375 correlated with a statistically significant decrease in malarial infection during the ongoing transmission season. The simultaneous presence of an antibody response to more than one antigen is indicative of a lower frequency of malarial infection. This gives scientific credibility to the notion that a successful malaria vaccine should contain multiple antigens.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Protozoan,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Protozoan,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Oligopeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Protozoan Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/QF116 antigen, Plasmodium falciparum,
http://linkedlifedata.com/resource/pubmed/chemical/glutamate-rich protein, Plasmodium,
http://linkedlifedata.com/resource/pubmed/chemical/merozoite surface protein 3...
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pubmed:status |
MEDLINE
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pubmed:issn |
0141-9838
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
265-72
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15541030-Animals,
pubmed-meshheading:15541030-Antibodies, Protozoan,
pubmed-meshheading:15541030-Antigens, Protozoan,
pubmed-meshheading:15541030-Burkina Faso,
pubmed-meshheading:15541030-Child,
pubmed-meshheading:15541030-Child, Preschool,
pubmed-meshheading:15541030-Cross-Sectional Studies,
pubmed-meshheading:15541030-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:15541030-Female,
pubmed-meshheading:15541030-Humans,
pubmed-meshheading:15541030-Immunoglobulin G,
pubmed-meshheading:15541030-Infant,
pubmed-meshheading:15541030-Longitudinal Studies,
pubmed-meshheading:15541030-Malaria, Falciparum,
pubmed-meshheading:15541030-Male,
pubmed-meshheading:15541030-Oligopeptides,
pubmed-meshheading:15541030-Plasmodium falciparum,
pubmed-meshheading:15541030-Protozoan Proteins
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pubmed:articleTitle |
Natural antibody response to Plasmodium falciparum Exp-1, MSP-3 and GLURP long synthetic peptides and association with protection.
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pubmed:affiliation |
Department of Biochemistry, University of Lausanne, Epalinges, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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