15536458

Source:http://linkedlifedata.com/resource/pubmed/id/15536458

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0010762, umls-concept:C0031437, umls-concept:C0031809, umls-concept:C0086418, umls-concept:C0330922, umls-concept:C0331428, umls-concept:C0697222, umls-concept:C0771607, umls-concept:C0886513, umls-concept:C1515075, umls-concept:C1515655
pubmed:issue	5
pubmed:dateCreated	2004-11-10
pubmed:abstractText	Phytochemical-mediated modulation of cytochrome P450 (CYP) activity may underlie many herb-drug interactions. Single-time point phenotypic metabolic ratios were used to determine whether long-term supplementation of Citrus aurantium , Echinacea purpurea , milk thistle (Silybum marianum), or saw palmetto (Serenoa repens) extracts affected CYP1A2, CYP2D6, CYP2E1, or CYP3A4 activity.
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/15536458
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0372741
pubmed:citationSubset	AIM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic Agents, http://linkedlifedata.com/resource/pubmed/chemical/Caffeine, http://linkedlifedata.com/resource/pubmed/chemical/Central Nervous System Stimulants, http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 Enzyme System, http://linkedlifedata.com/resource/pubmed/chemical/Debrisoquin, http://linkedlifedata.com/resource/pubmed/chemical/GABA Modulators, http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes, http://linkedlifedata.com/resource/pubmed/chemical/Midazolam, http://linkedlifedata.com/resource/pubmed/chemical/Permixon, http://linkedlifedata.com/resource/pubmed/chemical/Plant Extracts
pubmed:status	MEDLINE
pubmed:month	Nov
pubmed:issn	0009-9236
pubmed:author	pubmed-author:CarrierJulieJ, pubmed-author:EdwardsDavid JDJ, pubmed-author:GardnerStephanie FSF, pubmed-author:GentryW BrooksWB, pubmed-author:GurleyBill JBJ, pubmed-author:HubbardMartha AMA, pubmed-author:KhanIkhlas AIA, pubmed-author:ShahAmitA, pubmed-author:WilliamsD KeithDK
pubmed:issnType	Print
pubmed:volume	76
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	428-40
pubmed:dateRevised	2006-11-15
pubmed:meshHeading	pubmed-meshheading:15536458-Adrenergic Agents, pubmed-meshheading:15536458-Adult, pubmed-meshheading:15536458-Caffeine, pubmed-meshheading:15536458-Central Nervous System Stimulants, pubmed-meshheading:15536458-Chromatography, High Pressure Liquid, pubmed-meshheading:15536458-Citrus, pubmed-meshheading:15536458-Cytochrome P-450 Enzyme System, pubmed-meshheading:15536458-Debrisoquin, pubmed-meshheading:15536458-Dietary Supplements, pubmed-meshheading:15536458-Drug Interactions, pubmed-meshheading:15536458-Echinacea, pubmed-meshheading:15536458-Female, pubmed-meshheading:15536458-GABA Modulators, pubmed-meshheading:15536458-Humans, pubmed-meshheading:15536458-Isoenzymes, pubmed-meshheading:15536458-Kinetics, pubmed-meshheading:15536458-Male, pubmed-meshheading:15536458-Midazolam, pubmed-meshheading:15536458-Milk Thistle, pubmed-meshheading:15536458-Phenotype, pubmed-meshheading:15536458-Plant Extracts, pubmed-meshheading:15536458-Serenoa, pubmed-meshheading:15536458-Solubility
pubmed:year	2004
pubmed:articleTitle	In vivo assessment of botanical supplementation on human cytochrome P450 phenotypes: Citrus aurantium, Echinacea purpurea, milk thistle, and saw palmetto.
pubmed:affiliation	Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, College of Pharmacy, Little Rock, 72205, USA.
pubmed:publicationType	Journal Article, Clinical Trial, Randomized Controlled Trial, Research Support, Non-U.S. Gov't