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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
21
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pubmed:dateCreated |
2004-11-9
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pubmed:abstractText |
Loss of the methylthioadenosine phosphorylase (MTAP) gene at 9p21 is observed frequently in a variety of human cancers. We have shown previously that MTAP can act as a tumor suppressor gene and that its tumor suppressor function is related to its effect on polyamine homeostasis. Ornithine decarboxylase is a key enzyme in the regulation of polyamine metabolism. The aim of this study is to analyze MTAP and ornithine decarboxylase (ODC) expression in primary pancreatic tumor specimens.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7290-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15534104-Adenocarcinoma,
pubmed-meshheading:15534104-Apoptosis,
pubmed-meshheading:15534104-Blotting, Western,
pubmed-meshheading:15534104-Cell Line, Tumor,
pubmed-meshheading:15534104-Chromosomes, Human, Pair 9,
pubmed-meshheading:15534104-Cyclin-Dependent Kinase Inhibitor p16,
pubmed-meshheading:15534104-DNA,
pubmed-meshheading:15534104-Humans,
pubmed-meshheading:15534104-In Situ Hybridization, Fluorescence,
pubmed-meshheading:15534104-Models, Biological,
pubmed-meshheading:15534104-Neuroendocrine Tumors,
pubmed-meshheading:15534104-Ornithine Decarboxylase,
pubmed-meshheading:15534104-Pancreatic Neoplasms,
pubmed-meshheading:15534104-Polyamines,
pubmed-meshheading:15534104-Purine-Nucleoside Phosphorylase
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pubmed:year |
2004
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pubmed:articleTitle |
Loss of methylthioadenosine phosphorylase and elevated ornithine decarboxylase is common in pancreatic cancer.
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pubmed:affiliation |
Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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