Linked Life Data

15530552

Source:http://linkedlifedata.com/resource/pubmed/id/15530552

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2004-11-8
pubmed:abstractText
The distribution pattern of Edg-8 immunostaining in the human developing brain has been investigated with special reference to radial glial fibers. At 24 weeks of gestation, fragments of radial glial fibers are Edg-8-positive within the cortical plate and subplate of allocortical areas. These Edg-8-positive fragments often appear enlarged as varicosities and some of them terminate at blood vessels. Between 28 and 30 weeks of gestation, all iso- and allocortical areas contain Edg-8-immunolabelled radial glial fibers revealing curvature next to sulci. After 32 weeks of gestation, radial glial fibers gradually disappear; instead Edg-8-positive transitional stages between radial glia and astrocytes were found. The findings indicate that sphingosine-1-phosphate may play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0065-1281
pubmed:author
pubmed:issnType
Print
pubmed:volume
106
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
373-8
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Evidence for the presence of the sphingosine-1-phosphate receptor Edg-8 in human radial glial fibers.
pubmed:affiliation
Department of Anatomy, Neuroembryonic Research Laboratory, University of Rostock, Gertrudenstrasse 9, D-18055 Rostock, Germany. norbert.ulfig@med.uni-rostock.de
pubmed:publicationType
Journal Article