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rdf:type |
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lifeskim:mentions |
umls-concept:C0019704,
umls-concept:C0035668,
umls-concept:C0178539,
umls-concept:C0441889,
umls-concept:C0521026,
umls-concept:C0679058,
umls-concept:C0681842,
umls-concept:C1547699,
umls-concept:C1719797,
umls-concept:C1880019,
umls-concept:C1963724,
umls-concept:C2700640,
umls-concept:C2911648
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pubmed:issue |
11
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pubmed:dateCreated |
2004-11-5
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pubmed:abstractText |
To characterize newly arising replication of human immunodeficiency virus (HIV) type 1 in vivo at the cellular level, distinct viral RNA species in peripheral blood mononuclear cells (PBMCs) from HIV-1-infected patients were monitored during 2 weeks of structured treatment interruption (STI). HIV-1 RNA encoding tat/rev and PBMC-associated virions were almost completely depleted during antiretroviral therapy and emerged simultaneously after 2 weeks of STI, thus specifically reflecting productive viral infection at the cellular level. The magnitude of these correlates of reappearing cellular viral replication was predicted by during-therapy levels of nef transcripts in PBMCs. Significant rebound of plasma viremia, representing the progeny of a broader range of anatomical compartments, preceded and predicted productive infection in PBMCs. Thus, cellular viral rebound in PBMCs likely was primed before STI by the expression of nef in HIV-1-infected PBMCs that lacked virion production and was subsequently triggered by the plasma viremia that preceded the recurrence of productively infected PBMCs.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-HIV Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Gene Products, nef,
http://linkedlifedata.com/resource/pubmed/chemical/Gene Products, rev,
http://linkedlifedata.com/resource/pubmed/chemical/Gene Products, tat,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/nef Gene Products, Human...,
http://linkedlifedata.com/resource/pubmed/chemical/rev Gene Products, Human...,
http://linkedlifedata.com/resource/pubmed/chemical/tat Gene Products, Human...
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-1899
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
190
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1979-88
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15529263-Anti-HIV Agents,
pubmed-meshheading:15529263-Cells, Cultured,
pubmed-meshheading:15529263-Drug Therapy, Combination,
pubmed-meshheading:15529263-Gene Products, nef,
pubmed-meshheading:15529263-Gene Products, rev,
pubmed-meshheading:15529263-Gene Products, tat,
pubmed-meshheading:15529263-HIV Infections,
pubmed-meshheading:15529263-HIV-1,
pubmed-meshheading:15529263-Humans,
pubmed-meshheading:15529263-Leukocytes, Mononuclear,
pubmed-meshheading:15529263-Neutrophils,
pubmed-meshheading:15529263-RNA, Viral,
pubmed-meshheading:15529263-RNA Splicing,
pubmed-meshheading:15529263-Recurrence,
pubmed-meshheading:15529263-Virus Replication,
pubmed-meshheading:15529263-nef Gene Products, Human Immunodeficiency Virus,
pubmed-meshheading:15529263-rev Gene Products, Human Immunodeficiency Virus,
pubmed-meshheading:15529263-tat Gene Products, Human Immunodeficiency Virus
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pubmed:year |
2004
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pubmed:articleTitle |
Cellular viral rebound after cessation of potent antiretroviral therapy predicted by levels of multiply spliced HIV-1 RNA encoding nef.
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pubmed:affiliation |
Division of Infectious Diseases and Hospital Epidemiology, Department of Medicine, University Hospital Zurich, CH-8091 Zurich, Switzerland. marek.fischer@usz.ch
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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