Linked Life Data

15528305

Source:http://linkedlifedata.com/resource/pubmed/id/15528305

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2005-1-14
pubmed:abstractText
Neuropeptide Y (NPY) plays a major role in the regulation of food intake, regulation of homeostasis, and neuroendocrine function. We have previously shown that third ventricular infusion of this peptide delays the estradiol benzoate-induced surge in LH secretion in ovariectomized ewes. To determine the receptor subtype that transmits this effect, we have now used the same model to infuse a Y1 receptor agonist [NPY Leu31 Pro34], a Y2 receptor agonist (PYY3-36), and a Y4 receptor agonist (pancreatic polypeptide). We monitored the surges in animals given these agonists or artificial cerebrospinal fluid by measuring plasma LH levels, and we also measured daily voluntary food intake (VFI). A low (7 microg/h) dose of Y2 agonist delayed the surge but did not affect VFI, whereas a higher dose (14 microg/h) stimulated VFI. A dose of 18 microg/h of the Y1 agonist did not affect surge generation but also stimulated VFI. A dose of 24 microg/h of Y4 agonist affected neither surge generation nor VFI. These specificities are different from those reported for the rat and human (in which a Y2 agonist causes reduction in VFI). We conclude that, in sheep, the negative regulation of the reproductive axis by NPY and Y-receptor agonists is effected via the Y2 receptors, whereas the orexigenic effects are most likely effected via the Y1 receptors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Estrogens, http://linkedlifedata.com/resource/pubmed/chemical/Luteinizing Hormone, http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptide Y, http://linkedlifedata.com/resource/pubmed/chemical/Pancreatic Polypeptide, http://linkedlifedata.com/resource/pubmed/chemical/Peptide YY, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Neuropeptide Y, http://linkedlifedata.com/resource/pubmed/chemical/neuropeptide Y, Leu(31)-Pro(34)-, http://linkedlifedata.com/resource/pubmed/chemical/neuropeptide Y-Y1 receptor, http://linkedlifedata.com/resource/pubmed/chemical/neuropeptide Y2 receptor, http://linkedlifedata.com/resource/pubmed/chemical/neuropeptide Y4 receptor, http://linkedlifedata.com/resource/pubmed/chemical/peptide YY (3-36)
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0013-7227
pubmed:author
pubmed:issnType
Print
pubmed:volume
146
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
769-75
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Y2 receptor-selective agonist delays the estrogen-induced luteinizing hormone surge in ovariectomized ewes, but y1-receptor-selective agonist stimulates voluntary food intake.
pubmed:affiliation
Prince Henry's Institute of Medical Research, P.O. Box 5152, Clayton, Victoria 3168, Australia. iain.clarke@phimr.monash.edu.au
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't