|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0001613,
umls-concept:C0007776,
umls-concept:C0009240,
umls-concept:C0013227,
umls-concept:C0022655,
umls-concept:C0025255,
umls-concept:C0033414,
umls-concept:C0033634,
umls-concept:C0442805,
umls-concept:C1882598,
umls-concept:C1999177
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|
pubmed:issue |
16
|
|
pubmed:dateCreated |
1992-4-29
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|
pubmed:abstractText |
Protein Kinase C (PKC) activity was measured in soluble and particulate fractions of rat individual brain cortices after in vivo treatment with two cognition enhancers: oxiracetam and alpha-glicerylphosphorylcholine. Both drugs induced an increase (+40-50%) of PKC particulate activity at 1 hr after the treatment. The effect was transient; at 5 hours PKC activity was lower than in controls. The dose response curve to oxiracetam was bell shaped, the increase of PKC being significant at 100 mg/kg. At higher doses the drug induced a decrease in enzyme activity. The increased PKC activity may be related to the cortical effects of these compounds.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0024-3205
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
50
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
PL125-8
|
|
pubmed:dateRevised |
2007-11-15
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|
pubmed:meshHeading |
pubmed-meshheading:1552828-Animals,
pubmed-meshheading:1552828-Cerebral Cortex,
pubmed-meshheading:1552828-Cognition,
pubmed-meshheading:1552828-Desipramine,
pubmed-meshheading:1552828-Glycerylphosphorylcholine,
pubmed-meshheading:1552828-Male,
pubmed-meshheading:1552828-Protein Kinase C,
pubmed-meshheading:1552828-Pyrrolidines,
pubmed-meshheading:1552828-Rats,
pubmed-meshheading:1552828-Rats, Inbred Strains
|
|
pubmed:year |
1992
|
|
pubmed:articleTitle |
Protein kinase C increase in rat brain cortical membranes may be promoted by cognition enhancing drugs.
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|
pubmed:affiliation |
Pharmacobiology Dept., Univ. of Bari, Italy.
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|
pubmed:publicationType |
Journal Article
|
