rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2004-11-5
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pubmed:abstractText |
The molecular basis of the genetic vulnerability underlying the most common form of clinical tuberculosis (TB) remains largely unknown. We speculated that mild genetic defects in the interferon-gamma (IFN-gamma) signalling pathway caused a subtle functional impairment of IFN-gamma which would explain susceptibility to Mycobacterium tuberculosis in clinical TB.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DR Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, IgG,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interferon,
http://linkedlifedata.com/resource/pubmed/chemical/STAT1 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/STAT1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/interferon gamma receptor
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1027-3719
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1221-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15527154-Adult,
pubmed-meshheading:15527154-Case-Control Studies,
pubmed-meshheading:15527154-DNA-Binding Proteins,
pubmed-meshheading:15527154-Disease Susceptibility,
pubmed-meshheading:15527154-HLA-DR Antigens,
pubmed-meshheading:15527154-Humans,
pubmed-meshheading:15527154-Lipopolysaccharides,
pubmed-meshheading:15527154-Monocytes,
pubmed-meshheading:15527154-Receptors, IgG,
pubmed-meshheading:15527154-Receptors, Interferon,
pubmed-meshheading:15527154-STAT1 Transcription Factor,
pubmed-meshheading:15527154-Signal Transduction,
pubmed-meshheading:15527154-Trans-Activators,
pubmed-meshheading:15527154-Tuberculosis,
pubmed-meshheading:15527154-Tumor Necrosis Factor-alpha
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pubmed:year |
2004
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pubmed:articleTitle |
Functional and genetic assessment of IFN-gamma receptor in patients with clinical tuberculosis.
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pubmed:affiliation |
Department of Internal Medicine, Gachon Medical School, Gil Medical Centre, Incheon, South Korea. parkgy@gachon.md
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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