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pubmed-article:15523348pubmed:abstractTextAdverse changes in bone have been reported for patients undergoing high-dose, long-term (several years) isotretinoin therapy for disorders of cornification. The effect of short-term (4-5 months) therapy at the lower dose recommended for acne on bone development in younger, growing adolescent (12-17 years) patients has not been well studied.lld:pubmed
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pubmed-article:15523348pubmed:articleTitleEffect of a single course of isotretinoin therapy on bone mineral density in adolescent patients with severe, recalcitrant, nodular acne.lld:pubmed
pubmed-article:15523348pubmed:affiliationDivision of Dermatopharmacology, Department of Dermatology, Brown Medical School/Rhode Island Hospital, Providence, RI 02903, USA. John_DiGiovanna_MD@Brown.edulld:pubmed
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