Linked Life Data

15519886

Source:http://linkedlifedata.com/resource/pubmed/id/15519886

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2004-11-2
pubmed:abstractText
Activation of the AT(1) angiotensin receptor is a clinically important maladaptive response during cardiac hypertrophy. Autocrine and paracrine effects of locally generated angiotensin II, are believed to be the main mediators of these responses. However, a recent report has suggested that mechanical stress can activate AT(1) receptors independently of angiotensin II generation. This finding, as well as recent studies on intracrine effects and the pharmacological consequences of receptor hetero-oligomerization, suggest that unexpected mechanisms could contribute to the role of the renin-angiotensin system during cardiac hypertrophy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1043-2760
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
405-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
The role of the AT1 angiotensin receptor in cardiac hypertrophy: angiotensin II receptor or stretch sensor?
pubmed:affiliation
Department of Physiology, Semmelweis University, Faculty of Medicine, H-1088 Budapest, Hungary. hunyady@puskin.sote.hu
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't