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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2004-10-26
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pubmed:abstractText |
Glutathione (GSH) plays a key role in protection against oxidative stress. L-cysteine is thought to be rate-limiting for the synthesis of glutathione (GSH) and therefore may be a critical component in protection against oxidative stress. The purpose of this study was to investigate the role of L-cysteine in GSH metabolism and oxidative stress in human retinal pigment epithelial (hRPE) cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0146-0404
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
45
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4183-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15505073-Apoptosis,
pubmed-meshheading:15505073-Cell Survival,
pubmed-meshheading:15505073-Cells, Cultured,
pubmed-meshheading:15505073-Cysteine,
pubmed-meshheading:15505073-DNA,
pubmed-meshheading:15505073-Electron Transport Complex III,
pubmed-meshheading:15505073-Enzyme Inhibitors,
pubmed-meshheading:15505073-Glutathione,
pubmed-meshheading:15505073-Humans,
pubmed-meshheading:15505073-Membrane Potentials,
pubmed-meshheading:15505073-Mitochondria,
pubmed-meshheading:15505073-Oxidation-Reduction,
pubmed-meshheading:15505073-Oxidative Stress,
pubmed-meshheading:15505073-Permeability,
pubmed-meshheading:15505073-Pigment Epithelium of Eye,
pubmed-meshheading:15505073-Reactive Oxygen Species
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pubmed:year |
2004
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pubmed:articleTitle |
Cysteine starvation activates the redox-dependent mitochondrial permeability transition in retinal pigment epithelial cells.
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pubmed:affiliation |
Department of Biochemistry, National University of Singapore, Singapore.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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