Source:http://linkedlifedata.com/resource/pubmed/id/15500545
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
2004-10-25
|
| pubmed:abstractText |
Kisspeptin is the peptide product of the KiSS-1 gene and the endogenous agonist for the GPR54 receptor. Recent evidence suggests the kisspeptin/GPR54 system is a key regulator of the reproductive system. We examined the effect of intracerebroventricular (i.c.v.) and peripheral administration of the active kisspeptin fragment, kisspeptin-10, on circulating gonadotrophins and total testosterone levels in adult male rats. The effect of kisspeptin-10 in vitro on the release of hypothalamic peptides from hypothalamic explants and gonadotrophins from anterior pituitary fragments was also determined. The i.c.v. administration of kisspeptin-10 dose-dependently increased plasma luteinizing hormone (LH) and increased plasma follicle stimulating hormone (FSH) and total testosterone at 60 min postinjection. In a separate study investigating the time course of this response, i.c.v. administered kisspeptin-10 (3 nmol) significantly increased plasma LH at 10, 20 and 60 min, FSH at 60 min and total testosterone at 20 and 60 min postinjection. Kisspeptin-10 stimulated the release of luteinizing hormone-releasing hormone (LHRH) from in vitro hypothalamic explants. Peripheral administration of kisspeptin-10 increased plasma LH, FSH and total testosterone. However, doses of 100-1000 nM kisspeptin-10 did not influence LH or FSH release from pituitary fragments in vitro. Kisspeptin therefore potently stimulates the hypothalamic-pituitary-gonadal axis. These effects are likely to be mediated via the hypothalamic LHRH system.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Gonadotropins,
http://linkedlifedata.com/resource/pubmed/chemical/KISS1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Kisspeptins,
http://linkedlifedata.com/resource/pubmed/chemical/Oligopeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Pituitary Hormones,
http://linkedlifedata.com/resource/pubmed/chemical/Testosterone
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0953-8194
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
16
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
850-8
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:15500545-Animals,
pubmed-meshheading:15500545-Behavior, Animal,
pubmed-meshheading:15500545-Circadian Rhythm,
pubmed-meshheading:15500545-Dose-Response Relationship, Drug,
pubmed-meshheading:15500545-Eating,
pubmed-meshheading:15500545-Fasting,
pubmed-meshheading:15500545-Gonadotropins,
pubmed-meshheading:15500545-Hypothalamo-Hypophyseal System,
pubmed-meshheading:15500545-Injections, Intraventricular,
pubmed-meshheading:15500545-Kisspeptins,
pubmed-meshheading:15500545-Male,
pubmed-meshheading:15500545-Oligopeptides,
pubmed-meshheading:15500545-Pituitary Gland, Anterior,
pubmed-meshheading:15500545-Pituitary Hormones,
pubmed-meshheading:15500545-Rats,
pubmed-meshheading:15500545-Rats, Wistar,
pubmed-meshheading:15500545-Stimulation, Chemical,
pubmed-meshheading:15500545-Testis,
pubmed-meshheading:15500545-Testosterone
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
Central and peripheral administration of kisspeptin-10 stimulates the hypothalamic-pituitary-gonadal axis.
|
| pubmed:affiliation |
Department of Metabolic Medicine, Imperial College Faculty of Medicine, Hammersmith Campus, Du Cane Road, London W12 0NN, UK.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|