Linked Life Data

15497454

Source:http://linkedlifedata.com/resource/pubmed/id/15497454

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2004-10-22
pubmed:abstractText
Autoantibodies to thyroid peroxidase (TPO) predominately recognise conformational epitopes, restricted to two immunodominant regions (IDR) -A and -B. We have estimated the proportion of IDR-A and -B autoantibodies in 75 Hashimoto and 68 Graves patients sera. There were no statically significant differences between Hashimoto and Graves patients sera in the IDR-A and -B autoantibodies level, despite great differences between individual patients sera. In 75 Hashimoto patients sera, the mean value of IDR-A was 24.26%, IDR-B--52.26%, IDR (A + B)-76.66%, and to non-A, non-B regions--23.5%. In 68 Graves disease patients, the mean value of IDR-A was 24.87, IDR-B--54.29, IDR (A + B)--79.07, non-A, non-B--20.92%, at a single autoantibodies concentration 5IU/ml. At high autoantibodies concentration (50 IU/ml) the proportion of autoantibodies to the IDR (A + B) diminished to 58% and to the non-A, non-B TPO regions increased to 42%. The autoimmune response to TPO regions outside the IDR (A + B) epitopes is stronger then previously assumed and this response is also conformation dependent.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0891-6934
pubmed:author
pubmed:issnType
Print
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
211-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Proportion of antibodies to the A and B immunodominant regions of thyroid peroxidase in Graves and Hashimoto disease.
pubmed:affiliation
Medical Centre of Postgraduate Education, Clinical Biochemistry Department, 01-813, Warsaw, Poland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't