| pubmed-article:15479124 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15479124 | lifeskim:mentions | umls-concept:C0042401 | lld:lifeskim |
| pubmed-article:15479124 | lifeskim:mentions | umls-concept:C0020476 | lld:lifeskim |
| pubmed-article:15479124 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:15479124 | pubmed:dateCreated | 2004-10-13 | lld:pubmed |
| pubmed-article:15479124 | pubmed:abstractText | Atherogenic lipoproteins can cause endothelial dysfunction in the initial stage of atherogenesis. In our study we examined 134 patients with defined hyperlipoproteinemia (non-HDL cholesterol>4.1 mmol/l or triglycerides>2.5 mmol/l or taking any of lipid lowering drugs)--94 men and 40 women. The subgroup of controls of comparable age contained 54 normolipidemic individuals--30 men and 24 women. Patients with hyperlipoproteinemia revealed significantly lower ability of endothelium-dependent flow-mediated vasodilation (EDV) measured on brachial artery (4.13+/-3.07 vs. 5.41+/-3.82 %; p=0.032) and higher carotid intima media thickness than normolipidemic controls (0.68+/-0.22 vs. 0.58+/-0.15 mm; p=0.005). In regression analysis, EDV correlated significantly with plasma concentrations of oxLDL (p<0.05) HDL-cholesterol (p<0.05), Apo A1 (p<0.05), ATI (p<0.01) and non-HDL cholesterol (p<0.05). Patients with hyperlipoproteinemia showed higher plasma levels of oxLDL (65.77+/-9.54 vs. 56.49+/-7.80 U/l; p=0.015), malondialdehyde (0.89+/-0.09 vs. 0.73+/-0.08 micromol/l; p=0.010) and nitrites/nitrates (20.42+/-4.88 vs. 16.37+/-4.44 micromol/l; p=0.018) indicating possible higher long-term oxidative stress in these patients. | lld:pubmed |
| pubmed-article:15479124 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15479124 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15479124 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15479124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15479124 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15479124 | pubmed:issn | 0862-8408 | lld:pubmed |
| pubmed-article:15479124 | pubmed:author | pubmed-author:KoprivováHH | lld:pubmed |
| pubmed-article:15479124 | pubmed:author | pubmed-author:StípekSS | lld:pubmed |
| pubmed-article:15479124 | pubmed:author | pubmed-author:FialováLL | lld:pubmed |
| pubmed-article:15479124 | pubmed:author | pubmed-author:AndelMM | lld:pubmed |
| pubmed-article:15479124 | pubmed:author | pubmed-author:SyrovátkaPP | lld:pubmed |
| pubmed-article:15479124 | pubmed:author | pubmed-author:LUR'EA MAM | lld:pubmed |
| pubmed-article:15479124 | pubmed:author | pubmed-author:PotockováJJ | lld:pubmed |
| pubmed-article:15479124 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15479124 | pubmed:volume | 53 | lld:pubmed |
| pubmed-article:15479124 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15479124 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15479124 | pubmed:pagination | 471-80 | lld:pubmed |
| pubmed-article:15479124 | pubmed:dateRevised | 2008-4-2 | lld:pubmed |
| pubmed-article:15479124 | pubmed:meshHeading | pubmed-meshheading:15479124... | lld:pubmed |
| pubmed-article:15479124 | pubmed:meshHeading | pubmed-meshheading:15479124... | lld:pubmed |
| pubmed-article:15479124 | pubmed:meshHeading | pubmed-meshheading:15479124... | lld:pubmed |
| pubmed-article:15479124 | pubmed:meshHeading | pubmed-meshheading:15479124... | lld:pubmed |
| pubmed-article:15479124 | pubmed:meshHeading | pubmed-meshheading:15479124... | lld:pubmed |
| pubmed-article:15479124 | pubmed:meshHeading | pubmed-meshheading:15479124... | lld:pubmed |
| pubmed-article:15479124 | pubmed:meshHeading | pubmed-meshheading:15479124... | lld:pubmed |
| pubmed-article:15479124 | pubmed:meshHeading | pubmed-meshheading:15479124... | lld:pubmed |
| pubmed-article:15479124 | pubmed:meshHeading | pubmed-meshheading:15479124... | lld:pubmed |
| pubmed-article:15479124 | pubmed:meshHeading | pubmed-meshheading:15479124... | lld:pubmed |
| pubmed-article:15479124 | pubmed:meshHeading | pubmed-meshheading:15479124... | lld:pubmed |
| pubmed-article:15479124 | pubmed:meshHeading | pubmed-meshheading:15479124... | lld:pubmed |
| pubmed-article:15479124 | pubmed:meshHeading | pubmed-meshheading:15479124... | lld:pubmed |
| pubmed-article:15479124 | pubmed:meshHeading | pubmed-meshheading:15479124... | lld:pubmed |
| pubmed-article:15479124 | pubmed:meshHeading | pubmed-meshheading:15479124... | lld:pubmed |
| pubmed-article:15479124 | pubmed:meshHeading | pubmed-meshheading:15479124... | lld:pubmed |
| pubmed-article:15479124 | pubmed:meshHeading | pubmed-meshheading:15479124... | lld:pubmed |
| pubmed-article:15479124 | pubmed:meshHeading | pubmed-meshheading:15479124... | lld:pubmed |
| pubmed-article:15479124 | pubmed:meshHeading | pubmed-meshheading:15479124... | lld:pubmed |
| pubmed-article:15479124 | pubmed:meshHeading | pubmed-meshheading:15479124... | lld:pubmed |
| pubmed-article:15479124 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15479124 | pubmed:articleTitle | Hyperlipoproteinemia impairs endothelium-dependent vasodilation. | lld:pubmed |
| pubmed-article:15479124 | pubmed:affiliation | Second Department of Internal Medicine, Third Faculty of Medicine, Charles University, Srobárova 50, 100 00 Prague 10, Czech Republic. kraml@fnkv.cz | lld:pubmed |
| pubmed-article:15479124 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15479124 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:15479124 | pubmed:publicationType | Controlled Clinical Trial | lld:pubmed |
| pubmed-article:15479124 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
