Source:http://linkedlifedata.com/resource/pubmed/id/15479124
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2004-10-13
|
| pubmed:abstractText |
Atherogenic lipoproteins can cause endothelial dysfunction in the initial stage of atherogenesis. In our study we examined 134 patients with defined hyperlipoproteinemia (non-HDL cholesterol>4.1 mmol/l or triglycerides>2.5 mmol/l or taking any of lipid lowering drugs)--94 men and 40 women. The subgroup of controls of comparable age contained 54 normolipidemic individuals--30 men and 24 women. Patients with hyperlipoproteinemia revealed significantly lower ability of endothelium-dependent flow-mediated vasodilation (EDV) measured on brachial artery (4.13+/-3.07 vs. 5.41+/-3.82 %; p=0.032) and higher carotid intima media thickness than normolipidemic controls (0.68+/-0.22 vs. 0.58+/-0.15 mm; p=0.005). In regression analysis, EDV correlated significantly with plasma concentrations of oxLDL (p<0.05) HDL-cholesterol (p<0.05), Apo A1 (p<0.05), ATI (p<0.01) and non-HDL cholesterol (p<0.05). Patients with hyperlipoproteinemia showed higher plasma levels of oxLDL (65.77+/-9.54 vs. 56.49+/-7.80 U/l; p=0.015), malondialdehyde (0.89+/-0.09 vs. 0.73+/-0.08 micromol/l; p=0.010) and nitrites/nitrates (20.42+/-4.88 vs. 16.37+/-4.44 micromol/l; p=0.018) indicating possible higher long-term oxidative stress in these patients.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
0862-8408
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
53
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
471-80
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| pubmed:dateRevised |
2008-4-2
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| pubmed:meshHeading |
pubmed-meshheading:15479124-Age Distribution,
pubmed-meshheading:15479124-Aged,
pubmed-meshheading:15479124-Arteriosclerosis,
pubmed-meshheading:15479124-Causality,
pubmed-meshheading:15479124-Cohort Studies,
pubmed-meshheading:15479124-Comorbidity,
pubmed-meshheading:15479124-Czech Republic,
pubmed-meshheading:15479124-Dilatation, Pathologic,
pubmed-meshheading:15479124-Endothelium, Vascular,
pubmed-meshheading:15479124-Female,
pubmed-meshheading:15479124-Humans,
pubmed-meshheading:15479124-Hyperlipoproteinemias,
pubmed-meshheading:15479124-Incidence,
pubmed-meshheading:15479124-Lipoproteins,
pubmed-meshheading:15479124-Male,
pubmed-meshheading:15479124-Middle Aged,
pubmed-meshheading:15479124-Risk Assessment,
pubmed-meshheading:15479124-Risk Factors,
pubmed-meshheading:15479124-Sex Distribution,
pubmed-meshheading:15479124-Vasodilation
|
| pubmed:year |
2004
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| pubmed:articleTitle |
Hyperlipoproteinemia impairs endothelium-dependent vasodilation.
|
| pubmed:affiliation |
Second Department of Internal Medicine, Third Faculty of Medicine, Charles University, Srobárova 50, 100 00 Prague 10, Czech Republic. kraml@fnkv.cz
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| pubmed:publicationType |
Journal Article,
Clinical Trial,
Controlled Clinical Trial,
Research Support, Non-U.S. Gov't
|