Linked Life Data

15474154

Source:http://linkedlifedata.com/resource/pubmed/id/15474154

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2004-10-11
pubmed:abstractText
Cytogenetic findings were identified in 5 adrenal pheochromocytomas (PCC), including two clinically malignant tumors. The 3 PCC with benign clinical behavior, including one associated with von Hippel-Lindau syndrome, displayed no clonal chromosomal aberrations. In contrast, both clinically malignant PCC were characterized by hypotriploid chromosome numbers and multiple numerical and structural changes involving various chromosomes. Overall, losses were observed more frequently than gains. Aberrations common to both malignant tumors included losses of chromosomes 4, 11p, 13q, 15q, 16p, 17p, and 18, and partial gains of chromosome 7. The present results indicate that the malignant phenotype in PCC is associated with considerable genetic instability, leading to highly aneuploid and aberrant karyotypes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0165-4608
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
154
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
163-6
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Cytogenetic characterization of 5 pheochromocytomas.
pubmed:affiliation
Institute of Pathology, University of Göttingen, Germany.
pubmed:publicationType
Journal Article