Abnormal proinsulin processing in insulinomas may result in secretory granules containing both insulin and proinsulin, a finding not encountered in healthy beta-cells. The aim of this study was to test whether such abnormalities in the proinsulin to insulin conversion have clinical implications in patients with hypoglycaemic disorders.
Department of Internal Medicine, Division of Endocrinology and Diabetes, Institute for Diagnostic Radiology, University Hospital of Zurich, Switzerland. peter.wiesli@DIM.usz.ch