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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2004-10-8
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pubmed:abstractText |
Standardization of marrow dosimetry is of considerable importance when estimating dose-response for a multicentered clinical trial involving radionuclide therapy. However, it is only within the past five years that the intercomparison of marrow dosimetry results among separate clinical trials that use the same agent has become scientifically feasible. In this work, we have analyzed reported marrow dosimetry results from radioimmunotherapy trials and recalculated marrow absorbed doses at a central facility using a standard blood model with patient-specific source data. The basic approach used in the American Association of Physicists in Medicine (AAPM)/Sgouros marrow dosimetry methodology was common to calculation performed at all participating institutions, including the central facility. Differences in dose estimates associated with starting assumptions and the exact implementation of the AAPM/Sgouros calculation methodology used by the source institutions and the central facility were quantified and compared.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0161-5505
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
45
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1725-33
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15471841-Adult,
pubmed-meshheading:15471841-Aged,
pubmed-meshheading:15471841-Algorithms,
pubmed-meshheading:15471841-Antibodies,
pubmed-meshheading:15471841-Bone Marrow,
pubmed-meshheading:15471841-Female,
pubmed-meshheading:15471841-Humans,
pubmed-meshheading:15471841-Iodine Radioisotopes,
pubmed-meshheading:15471841-Male,
pubmed-meshheading:15471841-Metabolic Clearance Rate,
pubmed-meshheading:15471841-Middle Aged,
pubmed-meshheading:15471841-Models, Cardiovascular,
pubmed-meshheading:15471841-Radioimmunotherapy,
pubmed-meshheading:15471841-Radioisotope Dilution Technique,
pubmed-meshheading:15471841-Radioisotopes,
pubmed-meshheading:15471841-Radiometry,
pubmed-meshheading:15471841-Radiopharmaceuticals,
pubmed-meshheading:15471841-Radiotherapy Dosage,
pubmed-meshheading:15471841-Rhenium,
pubmed-meshheading:15471841-Risk Assessment,
pubmed-meshheading:15471841-Risk Factors,
pubmed-meshheading:15471841-United States
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pubmed:year |
2004
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pubmed:articleTitle |
Bone marrow dosimetry using blood-based models for radiolabeled antibody therapy: a multiinstitutional comparison.
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pubmed:affiliation |
Department of Radiation Oncology, Case Western Reserve University, Cleveland, Ohio.
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pubmed:publicationType |
Journal Article,
Guideline,
Clinical Trial,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study
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