Linked Life Data

1547059

Source:http://linkedlifedata.com/resource/pubmed/id/1547059

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1992-4-23
pubmed:abstractText
Erythrocyte acetylcholinesterase (AChE) activities in vivo were measured over 60 min using a spectrophotometric method after administration of neostigmine or edrophonium for antagonism of pancuronium-induced neuromuscular block in 31 patients. Erythrocyte AChE activities decreased to 11.3 (SD 1.2)% and 11.4 (0.8)% of baseline values (P less than 0.001) within 2 min, then recovered slowly and were 43.2 (6.2)% and 27.9 (2.9)% (P less than 0.001) 60 min after administration of neostigmine 0.036 mg kg-1 and 0.071 mg kg-1, respectively. However, the enzyme activity after edrophonium 1.43 mg kg-1 did not change significantly over 60 min. The results suggest that mechanisms other than AChE inhibition may be responsible for the anti-curare effect of edrophonium.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0007-0912
pubmed:author
pubmed:issnType
Print
pubmed:volume
68
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
316-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Effects of neostigmine and edrophonium on human erythrocyte acetylcholinesterase activity.
pubmed:affiliation
Department of Anaesthesiology, Tohoku University School of Medicine, Sendai, Japan.
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial, Research Support, Non-U.S. Gov't