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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2005-2-9
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pubmed:abstractText |
CDP860 is an engineered Fab' fragment-polyethylene glycol conjugate, which binds to and blocks the activity of the beta-subunit of the platelet-derived growth factor receptor (PDGFR-beta). Studies in animals have suggested that PDGFR-beta inhibition reduces tumor interstitial fluid pressure, and thus increases the uptake of concomitantly administered drugs. The purpose of this study was to determine whether changes in tumor vascular parameters could be detected in humans, and to assess whether CDP860 would be likely to increase the uptake of a concurrently administered small molecule in future studies.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0732-183X
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pubmed:author |
pubmed-author:BroughtonLL,
pubmed-author:BuckleyD LDL,
pubmed-author:CarringtonBB,
pubmed-author:CheungSS,
pubmed-author:DaviesKK,
pubmed-author:IssaBB,
pubmed-author:JacksonAA,
pubmed-author:JaysonG CGC,
pubmed-author:LawranceJJ,
pubmed-author:MullamithaSS,
pubmed-author:ParkerG J MGJ,
pubmed-author:RobertsCC,
pubmed-author:RolffMM,
pubmed-author:SaundersMM,
pubmed-author:ValleJ WJW,
pubmed-author:WatsonYY,
pubmed-author:Zinkewich-PéottiKK
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
973-81
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15466784-Adult,
pubmed-meshheading:15466784-Aged,
pubmed-meshheading:15466784-Ascites,
pubmed-meshheading:15466784-Capillary Permeability,
pubmed-meshheading:15466784-Colonic Neoplasms,
pubmed-meshheading:15466784-Contrast Media,
pubmed-meshheading:15466784-Extracellular Fluid,
pubmed-meshheading:15466784-Female,
pubmed-meshheading:15466784-Follow-Up Studies,
pubmed-meshheading:15466784-Humans,
pubmed-meshheading:15466784-Image Processing, Computer-Assisted,
pubmed-meshheading:15466784-Immunoglobulin Fab Fragments,
pubmed-meshheading:15466784-Magnetic Resonance Imaging,
pubmed-meshheading:15466784-Male,
pubmed-meshheading:15466784-Middle Aged,
pubmed-meshheading:15466784-Ovarian Neoplasms,
pubmed-meshheading:15466784-Pleural Effusion,
pubmed-meshheading:15466784-Polyethylene Glycols,
pubmed-meshheading:15466784-Receptor, Platelet-Derived Growth Factor beta,
pubmed-meshheading:15466784-Rectal Neoplasms,
pubmed-meshheading:15466784-Regional Blood Flow,
pubmed-meshheading:15466784-Tumor Burden
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pubmed:year |
2005
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pubmed:articleTitle |
Blockade of platelet-derived growth factor receptor-beta by CDP860, a humanized, PEGylated di-Fab', leads to fluid accumulation and is associated with increased tumor vascularized volume.
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pubmed:affiliation |
Cancer Research UK, Department of Medical Oncology, Christie Hospital, Manchester M20 4BX, United Kingdom. Gordon.Jayson@christie-tr.nwest.nhs.uk
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't,
Clinical Trial, Phase II
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