Source:http://linkedlifedata.com/resource/pubmed/id/15465291
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2004-10-6
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| pubmed:abstractText |
Cerebral bioenergetic and phospholipid abnormalities have been reported in heroin-dependent subjects. The goal of the present study was to characterize the neurochemical profile of subjects voluntarily enrolled in a methadone maintenance (MM) treatment program to overcome their heroin addiction. Participants included 43 heroin-dependent subjects during their first month of MM and 15 age-matched healthy individuals. Phosphorus magnetic resonance spectroscopy ((31)P MRS) and transverse relaxation times (T2-RT), which can reflect steady state cerebral perfusion and metabolism, were acquired at 1.5 T from an axial slice prescribed through the orbitofrontal and occipital cortices, including basal ganglia and frontal cortex. MM subjects exhibited reduced phosphocreatine (PCr) levels (-15.3%), elevated phosphodiesters (+ 12.9%, PDE) and significantly longer T2-RT ((+) 2.1%) compared with healthy comparison subjects. When MM subjects were stratified into subgroups based on treatment duration, we found a treatment duration effect on metabolite values but not T2-RT; reduced PCr was observed only after 8+ days of MM, and phosphomonoesters (PME) were elevated in the 15-28 day MM group. Taken together, these cross-sectional data suggest that the first month of MM treatment may be associated with altered cerebral bioenergetics and phospholipid metabolite levels.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Triphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Methadone,
http://linkedlifedata.com/resource/pubmed/chemical/Narcotics,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphocreatine,
http://linkedlifedata.com/resource/pubmed/chemical/Phospholipids,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphorus
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| pubmed:status |
MEDLINE
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| pubmed:month |
Sep
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| pubmed:issn |
0165-1781
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
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| pubmed:volume |
131
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
217-26
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| pubmed:dateRevised |
2008-4-17
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| pubmed:meshHeading |
pubmed-meshheading:15465291-Adenosine Triphosphate,
pubmed-meshheading:15465291-Adult,
pubmed-meshheading:15465291-Basal Ganglia,
pubmed-meshheading:15465291-Cerebral Cortex,
pubmed-meshheading:15465291-Cross-Sectional Studies,
pubmed-meshheading:15465291-Energy Metabolism,
pubmed-meshheading:15465291-Female,
pubmed-meshheading:15465291-Heroin Dependence,
pubmed-meshheading:15465291-Humans,
pubmed-meshheading:15465291-Image Processing, Computer-Assisted,
pubmed-meshheading:15465291-Magnetic Resonance Imaging,
pubmed-meshheading:15465291-Magnetic Resonance Spectroscopy,
pubmed-meshheading:15465291-Male,
pubmed-meshheading:15465291-Methadone,
pubmed-meshheading:15465291-Narcotics,
pubmed-meshheading:15465291-Phosphocreatine,
pubmed-meshheading:15465291-Phospholipids,
pubmed-meshheading:15465291-Phosphorus,
pubmed-meshheading:15465291-Regional Blood Flow,
pubmed-meshheading:15465291-Substance Abuse Detection,
pubmed-meshheading:15465291-Substance Withdrawal Syndrome
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| pubmed:year |
2004
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| pubmed:articleTitle |
Cerebral phosphorus metabolite and transverse relaxation time abnormalities in heroin-dependent subjects at onset of methadone maintenance treatment.
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| pubmed:affiliation |
Brain Imaging Center, McLean Hospital, Department of Psychiatry, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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