Linked Life Data

15459669

Source:http://linkedlifedata.com/resource/pubmed/id/15459669

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2004-10-1
pubmed:abstractText
Tumour-necrosis factor receptor (TNFR)-associated factors (TRAFs) are cytoplasmic adaptor proteins that are important in lymphocyte activation and apoptosis. Many studies of TRAFs have used models of exogenous overexpression by non-lymphoid cells. However, the actions of TRAFs present at normal levels in lymphoid cells often differ considerably from those that have been established in non-lymphocyte overexpression models. As I discuss here, information obtained from studying these molecules in physiological settings in B cells reveals that they have several roles, which are both unique and overlapping. These include activation of kinases and transcription factors, and interactions with other signalling proteins, culminating in the induction or inhibition of biological functions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1474-1733
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
775-86
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
The multifaceted roles of TRAFs in the regulation of B-cell function.
pubmed:affiliation
Department of Microbiology, The University of Iowa, Veterans' Affairs Medical Center, Iowa City, Iowa 52242, USA. gail-bishop@uiowa.edu
pubmed:publicationType
Journal Article, Review