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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2004-9-29
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pubmed:abstractText |
Cysteinyl leukotriene receptor 2 (CYSLTR2) is one of the receptors for the cysteinyl leukotrienes (CYSLTs), which cause bronchoconstrictions, vascular hyperpermeability and mucus hypersecretion in asthmatic patients. CYSLTR1 antagonists have been shown to be effective in the treatment of chronic asthma. CYSLTR2 is located approximately 300 kb from D13S153, which is reportedly linked to asthma in several populations. We characterized the genomic structure of humans CYSLTR2, determined the putative major promoter region and conducted association studies pertaining to polymorphisms in CYSLTR2 and asthma.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0960-314X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
683-90
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15454733-5' Untranslated Regions,
pubmed-meshheading:15454733-Amino Acid Sequence,
pubmed-meshheading:15454733-Asthma,
pubmed-meshheading:15454733-Base Sequence,
pubmed-meshheading:15454733-Child,
pubmed-meshheading:15454733-Chromosomes, Human, Pair 13,
pubmed-meshheading:15454733-DNA, Complementary,
pubmed-meshheading:15454733-Exons,
pubmed-meshheading:15454733-Gene Expression,
pubmed-meshheading:15454733-Humans,
pubmed-meshheading:15454733-Japan,
pubmed-meshheading:15454733-Linkage Disequilibrium,
pubmed-meshheading:15454733-Membrane Proteins,
pubmed-meshheading:15454733-Molecular Sequence Data,
pubmed-meshheading:15454733-Polymorphism, Genetic,
pubmed-meshheading:15454733-Polymorphism, Single Nucleotide,
pubmed-meshheading:15454733-Promoter Regions, Genetic,
pubmed-meshheading:15454733-Receptors, Leukotriene,
pubmed-meshheading:15454733-Tissue Distribution
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pubmed:year |
2004
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pubmed:articleTitle |
Association between a polymorphism in cysteinyl leukotriene receptor 2 on chromosome 13q14 and atopic asthma.
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pubmed:affiliation |
Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, 305-8575, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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