Source:http://linkedlifedata.com/resource/pubmed/id/15448101
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
2004-9-27
|
| pubmed:abstractText |
To clarify heterogeneity in Japanese adult-onset type 1 diabetes, we analyzed the HLA-DR and -DQ haplotypes, depending on the clinical phenotype, and compared them with those in childhood-onset type 1 diabetes (CO). The patients in a previously reported Ehime Study were divided into subgroups by the mode of onset of diabetes: 68 acute-onset type 1 diabetic patients (AO) and 28 slowly progressive type 1 diabetic patients (SO). HLA haplotypes were compared with those of 80 CO patients and 190 control subjects. Two major susceptible HLA haplotypes in the Japanese, DRB1*0405-DQB1*0401 (DR4) and DRB1*0901-DQB1*0303 (DR9), were significantly increased in the AO and CO groups, but only DR9 was increased in the SO group. AO subjects had a higher frequency of DR9 than CO subjects. Accordingly, the DR9:DR4 frequency increased with increasing age of onset. Another susceptible haplotype, DRB1*0802-DQB1*0302 (DR8), was involved only in the CO group. Analysis of haplotype combinations revealed that DR4 and DR9 had significant dosage effects on the AO and CO groups (P < 0.0001), but only DR9 had such an effect in the SO group (P < 0.03). These results suggest differences in the contribution of HLA class II haplotypes to susceptibility of type 1 diabetes depending on the clinical phenotype and also indicate that HLA class II haplotypes may be associated with the onset age of type 1 diabetes.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Oct
|
| pubmed:issn |
0012-1797
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| pubmed:author |
pubmed-author:EbisuiOsamuO,
pubmed-author:FujiiYasuhisaY,
pubmed-author:FujiyamaMasaoM,
pubmed-author:GraffC ACA,
pubmed-author:KainoYukikazuY,
pubmed-author:KatoKenichiK,
pubmed-author:KawasakiEijiE,
pubmed-author:KidaKaichiK,
pubmed-author:KondoShioriS,
pubmed-author:KonoueEtsushiE,
pubmed-author:KusunokiYukikoY,
pubmed-author:MakinoHideichiH,
pubmed-author:MuraoSatoshiS,
pubmed-author:NishimiyaTatsuyaT,
pubmed-author:OhashiJunJ,
pubmed-author:OhnoKeizoK,
pubmed-author:OnumaHiroshiH,
pubmed-author:OsawaHaruhikoH,
pubmed-author:ShimizuIkkiI,
pubmed-author:TakadaYasuharuY,
pubmed-author:TakemotoKojiK,
pubmed-author:TanabeKatsuyaK,
pubmed-author:TanakaKiyonobuK,
pubmed-author:TarumiYoshinaoY
|
| pubmed:issnType |
Print
|
| pubmed:volume |
53
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2684-90
|
| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:15448101-Adult,
pubmed-meshheading:15448101-Age of Onset,
pubmed-meshheading:15448101-Child,
pubmed-meshheading:15448101-Diabetes Mellitus, Type 1,
pubmed-meshheading:15448101-Gene Frequency,
pubmed-meshheading:15448101-Genetic Predisposition to Disease,
pubmed-meshheading:15448101-HLA-DQ Antigens,
pubmed-meshheading:15448101-HLA-DR Antigens,
pubmed-meshheading:15448101-Humans,
pubmed-meshheading:15448101-Japan
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
Differences in the contribution of HLA-DR and -DQ haplotypes to susceptibility to adult- and childhood-onset type 1 diabetes in Japanese patients.
|
| pubmed:affiliation |
Matsuyama Shimin Hospital, Ehime, Japan.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|